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Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
(Wiley, 2020-09-22)
Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver ...
Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
(Frontiers Media, 2021-06-08)
[EN] Essential tremor (ET) is a highly prevalent neurological disorder characterized by actioninduced
tremors involving the hand, voice, head, and/or face. Importantly, hand tremor
is present in nearly all forms of ET, ...
In Vitro P38MAPK Inhibition in Aged Astrocytes Decreases Reactive Astrocytes, Inflammation and Increases Nutritive Capacity After Oxygen-Glucose Deprivation
(Impact Journals LLC, 2021-03-15)
Proper astroglial functioning is essential for the development and survival of neurons and oligodendroglia under physiologic and pathological circumstances. Indeed, malfunctioning of astrocytes represents an important ...
The challenge of the contemporary theatre director bringing king lear to stage.
(2020-12-18)
Tras exponer como un método de investigación tradicional se queda en la superficialidad a la hora de lidiar con la esencia del teatro, esta tesis ofrece una novedosa investigación teórico-práctica basada en la metodología ...
Modelling and control for the oscillating water column
(2020-07-17)
Renewable energies are definitely part of the equation to limit our dependence to fossil fuels. Within this sector, ocean energies, and especially wave energy, represent a huge potential but is still a growing area. And ...
Surface enhanced Raman scattering (SERS) bioimaging of complex 3D cellu-lar systems
(2022-06-17)
Esta tesis se ha centrado en la dispersión Raman mejorada en superficie (SERS) como técnica de bioimagen, en particular para la observación de sistemas biológicos tridimensionales (3D) de células tumorales. Para esta ...
Lean Manufacturing and Environmental Sustainability: The Effects of Employee Involvement, Stakeholder Pressure and ISO 14001
(MDPI, 2020-09-04)
This paper explores the relationships between lean manufacturing (LM), the promotion of green practices, employee involvement, pressure to take actions against environmental issues, the adoption of an ISO 14001-based ...
Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response
(MDPI, 2020-08-24)
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against ...
The role of TREM-2 receptor in cholestasis and fibrosis-associated hepatocellular carcinoma (HCC)
(2020-12-18)
La progresión de enfermedades hepatobiliares crónicas, tales como las enfermedades colestásicas (entrelas que destacan la colangitis biliar primaria y la colangitis esclerosante primaria), así como el carcinomahepatocelular ...
Landsat and Sentinel-2 Based Burned Area Mapping Tools in Google Earth Engine
(MDPI, 2021-02-23)
Four burned area tools were implemented in Google Earth Engine (GEE), to obtain regular processes related to burned area (BA) mapping, using medium spatial resolution sensors (Landsat and Sentinel-2). The four tools are ...