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Transannular Approach to 2,3-Dihydropyrrolo[1,2‑b]isoquinolin- 5(1H)‑ones through Brønsted Acid-Catalyzed Amidohalogenation
(ACS. American Chemical Society, 2022-07-26)
A transannular approach has been developed for the construction of pyrrolo[1,2-b]isoquinolinones starting from benzofused nine-membered enelactams. This process takes place in the presence of a halogenating agent and under ...
Aplicación de procesos de micro fabricación de alta productividad para la fabricación de componentes poliméricos funcionales de interés en el sector biomédico
(2023-12-05)
El objetivo de la tesis se centra en el desarrollo de una metodología para el procesado de polímeros bio-absorbibles mediante tecnologías de alta productividad para la obtención de componentes micro-estructurados implantables. ...
Space-time symmetries in classical and quantum electromagnetic scattering theory
(2023-12-01)
In this thesis we propose a novel approach to study electromagnetic wave dynamics based on thesystematic application of group theory. We show that this alternative approach leads to new insights onwell-studied topics such ...
Delays in relativistic and non-relativistic scattering studied by means of quantum measurement theory
(2023-12-11)
Al medir el tiempo que toma un paquete de ondas en cruzar una región potencial a través del efecto túnel el resultado es aparentemente superluminal. La razón de esta medida paradójica se debe a que el paquete se remodela ...
Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids
(Royal Society of Chemistry, 2021-03-15)
The 8-azabicyclo[3.2.1]octane scaffold is the central core of the family of tropane alkaloids, which display a wide array of interesting biological activities. As a consequence, research directed towards the preparation ...
An Approach to the Synthesis of a Hepatitis C Virus Inhibitor through a Proline-Catalyzed 1,3-Dipolar Cycloaddition Using Acrolein
(Thieme, 2021-09-06)
An efficient and easy protocol for performing 1,3-dipolar cycloaddition using azomethine ylides and acrolein is presented. The reaction catalyzed by d-proline allows the synthesis of C-3 unsubstituted pyrrolidines. The ...
Enantioselective Synthesis of Tropanes: Brønsted Acid Catalyzed Pseudotransannular Desymmetrization
(Wiley-VCH, 2020-02-10)
The enantioselective synthesis of tropanols has been accomplished through chiral phosphoric acid catalyzed pseudotransannular ring opening of 1-aminocyclohept-4-ene-derived epoxides. The reaction proceeds together with the ...
Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis
(Royal Society of Chemistry, 2020-09-28)
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes ...
Recent Developments in Transannular Reactions
(Thieme, 2022-07-21)
Transannular reactions have shown a remarkable performance for the construction of polycyclic scaffolds from medium- or large-sized cyclic molecules in an unconventional manner. Recent examples of transannular reactions ...
Prediction of Antileishmanial Compounds: General Model, Preparation, and Evaluation of 2‑Acylpyrrole Derivatives
(ACS, 2022-08-10)
In this work, the SOFT.PTML tool has been used to pre-process a
ChEMBL dataset of pre-clinical assays of antileishmanial compound candidates.
A comparative study of different ML algorithms, such as logistic regression
(LOGR), ...