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Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
(Springer Nature, 2020-03)
Identification of genomic and epigenomic determinants of drug resistance provides important insights for improving cancer treatment. Using agnostic genome-wide interrogation of mRNA and miRNA expression, DNA methylation, ...
Synthesis of Waterborne Anticorrosive Coatings Based on The Incorporation of Phosphate Groups to Polyurethane-Acrylate Hybrids
(Wiley, 2023-08)
In this work, solvent-free waterborne polyurethane-poly(meth)acrylate hybrid dispersions that can be used to formulate anticorrosive paints are synthesized. To achieve the anticorrosive protection, a phosphate containing ...
Experimental and Numerical Characterization of Mechanical Behavior and Wear Pattern of Vitreous Bonding Grinding Wheels
(2023-12-15)
Introducción al Rectificado y el Papel de las Muelas Abrasivas: El rectificado es esencial en la manufactura para obtener tolerancias precisas y componentes duraderos. Los avances recientes se centran en mejorar la tecnología ...
Desinformación y credibilidad en el ecosistema digital: actas del XII Congreso Internacional de Ciberperiodismo
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2021)
Conjugative Coupling Proteins and the Role of Their Domains in Conjugation, Secondary Structure and in vivo Subcellular Location
(Frontiers Media, 2020-08-11)
Type IV Coupling Proteins (T4CPs) are essential elements in many type IV secretion systems (T4SSs). The members of this family display sequence, length, and domain architecture heterogeneity, being the conserved ...
Extension and improvement of synchronous linear generator based point absorber operation in high wave excitation scenarios
(Elsevier, 2021-11-01)
[EN]The exploitation of marine wave energy resource has led to the design of numerous Wave Energy Converter (WEC) configurations. The power absorption of a WEC is tightly related to its physical properties and the ...
Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase
(MDPI, 2021-11-30)
The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this protein, the toxicity of its aggregation intermediates and the ...
Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review
(Elsevier, 2021-09)
Diffuse large B-cell lymphoma (DLBCL), the most common type of Non-Hodgkin lymphoma (NHL), is a highly heterogeneous and aggressive disease. Regardless of this heterogeneity, all patients receive the same first-line therapy, ...
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group
(Elsevier, 2022-02)
[EN] BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. Comparison of incidence of allergic reactions to pegylated ...
Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study
(Wiley, 2022-06)
[EN] Background White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome ...