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Cointegration analysis of money demand in the Euro Area
(2014-06-24)
The analysis of the evolution of the M3 money aggregate is an important element in
the definition and implementation of monetary policy for the ECB. A well-defined and stable
long run demand function is an essential ...
The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals
(Public Library Science, 2014-04-17)
Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial ...
Reform of Spain's profesional services market: Implementation of the EU Services Directive
(FUNCAS, 2014-07)
The implementation of the European Commission Services Directive initiated the modernization process of services markets within the European Union. The objective was to guarantee the creation of a single market by ensuring ...
Association between CASP8-652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study
(Public Library Science, 2014-01)
The common 2652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) ...
The Computer Input/Output Subsystem Education in an undergraduate introductory course: a Multiperspective Study
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2014-02-24)
Tesi hau informatikaren irakaskuntzaren ikerkuntza lerroaren barruan kokatzen
da. Oinarri gisa, teknologia, pedagogia eta edukien ezagutza eredua
(TPACK model, bere ingeleseko sigletatik) hartzen du. Ikerketa ...
Hydrazides and hydrazones as versatile Michael-Donors for iminium-catalyzed conjugate addition reactions
(2014-02-06)
In the work compiled in this thesis is presented a series of strategies that have been studied and have lead to the asymmetric synthesis of useful building blocks in high yields and stereochemical control. These are reliant ...
Asymmetric organocatalytic cascade reactions
(2014-03-12)
[ES]En la presente memoria se recoge el trabajo de investigación enmarcado en elempleo de aminas secundarias quirales como organocatalizadores para el diseño dereacciones en cascada con el fin de obtener compuestos de ...
Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases
(Public Library Science, 2014-08-14)
Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. ...
Differential activity of GSK-3 isoforms regulates NF-kappa B and TRAIL- or TNF alpha induced apoptosis in pancreatic cancer cells
(Nature Publishing Group, 2014-03)
While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting ...
Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients
(Hindawi Publishing, 2014)
Targeting epidermal growth factor receptor (EGFR) has been one of the most effective colorectal cancer strategies. Anti-EGFR antibodies function by binding to the extracellular domain of EGFR, preventing its activation, ...