Search
Now showing items 1251-1260 of 1260
El Gravetiense en el Pirineo occidental: dinámicas de aprovisionamiento y gestión tecnológica de las materias primas líticas
(2019-10-24)
La presente tesis doctoral está dedicada al estudio integral de las industrias líticas de las comunidades humanas del Gravetiense en el Pirineo occidental. Para ello, nos hemos servido de una metodología contrastada y de ...
Altered nuclear export signal recognition as a driver of oncogenesis
(AACR, 2019-10-01)
Altered expression of XPO1, the main nuclear export receptor in eukaryotic cells, has been observed in cancer, and XPO1 has been a focus of anticancer drug development. However, mechanistic evidence for cancer-specific ...
Brønsted Base Catalyzed One-Pot Synthesis od Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition
(Wiley-VCH, 2019-07-31)
Acatalyst-driven one-pot reaction sequence is
developed for the enantio- and diastereoselective synthesis of
tetrasubstituted cyclohexenes from simple unsaturated ketones
or thioesters.The method involves atertiary ...
Detailed dissection of UBE3A-mediated DDI1 ubiquitination.
(Frontiers, 2019-05-03)
The ubiquitin E3 ligase UBE3A has been widely reported to interact with the proteasome, but it is still unclear how this enzyme regulates by ubiquitination the different proteasomal subunits. The proteasome receptor DDI1 ...
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
(Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ...
Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters: Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes
(Wiley-VCH, 2019-07-18)
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and ...
Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis
(Wiley, 2019-03-21)
Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts ...
Asymmetric a-functionalization of cyclid ketones promoted by bronsted base/H-bond catalysts.
(2019-11-18)
En esta tesis doctoral se han desarrollado nuevas metodologías para la -funcionalización regio- y estereoselectiva de cetonas cíclicas. Para ello se han empleado catalizadores con carácter bifuncional base de Brønsted/dador ...
Asymmetric a-functionatlization of barbituric acids via bronsted base catalysis.
(2019-01-18)
El objetivo de esta tesis ha sido lograr la ¿-desimetrización de amidas por medio de la organocatálisis.Este estudio ha sido enfocado a dos subconjuntos de amidas: derivados del ácido barbitúrico y ¿-iminoamidas, debido a ...
Bronsted base catalysed asymmetric C-C Bond-Forming reactions with unsaturated ketones.
(2019-12-13)
En esta tesis doctoral se han desarrollado nuevas metodologías para la funcionalización organocatalítica asimétrica de cetonas insaturadas empleando catalizadores bifuncionales de tipo Base de Brønsted/dador de enlace de ...