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22-tik 11-20 emaitza erakusten
Characterization of the HIV-1 membrane and its interactions with anti-viral compounds using advanced microscopy techniques
(2017-12-19)
El virus de la inmunodeficiencia humana (VIH) es un retrovirus perteneciente al género Lentivirus que infecta principalmente linfocitos T CD4+. El síndrome de inmunodeficiencia adquirida (SIDA) es un espectro de enfermedades ...
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons
(Biomed Central, 2017-04-11)
Background: Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates ...
Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes
(Elsevier, 2017-04)
We provide detailed datasets from our analysis of the proteins that associate with IL-2Rbeta and IL-2Rgamma in T-cells stimulated with IL-2 or IL-15 compared with resting T-cells, as identified by SILAC-based quantitative ...
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes
(MDPI, 2017-09-21)
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and ...
Structure-function relationships of tumor suppresor ING5
(2017-07-04)
La familia ING (INhibitor of Growth) de supresores tumorales está formada por cinco proteínas homólogas que regulan el estado transcripcional de la cromatina por medio del reclutamiento de complejos remodeladores de cromatina ...
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
(2017-01-13)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by ...
Identification and in vitro characterization of two new PCSK9 Gain of Function variants found in patients with Familial Hypercholesterolemia
(Nature, 2017-11)
Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by pathogenic variants in genes encoding for LDL receptor (LDLR), Apolipoprotein B and Proprotein convertase subtilisin/kexin type 9 (PCSK9). Among ...
G protein-membrane interactions II: Effect of G Protein-linked Lipids on Membrane Structure and G Protein-membrane Interactions
(Elsevier, 2017-07-03)
[EN] G proteins often bear myristoyl, palmitoyl and isoprenyl moieties, which favor their
association with the membrane and their accumulation in G Protein Coupled Receptor-rich
microdomains. These lipids influence the ...
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ...
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
(Nature Publishing, 2017-11-15)
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...