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Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
(MDPI, 2015-05)
Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of ...
Membrane properties of ceramide: a fluorescence spectroscopic and microscopic study
(2017-02-24)
Las membranas biológicas son complejas estructuras con una base lipídica y cruciales para lasupervivencia y función de las células. La ceramida es un lípido de membrana con unas característicasfísico-químicas singulares, ...
Regulation of inflammatory processes by ceramide kinase and phosphatidylethanolamine N-methyltransferase in lung cells, adipocytes and liver tissue.
(2019-05-31)
Nowadays, around 60% of the world's population dies due to chronic inflammatory conditions, such as chronic respiratory diseases, obesity, fatty liver disease and cancer. All these pathologies are associated to alterations ...
Mechanical and structural studies of internal lipid-containing bacteriophage PRD1.
(2018-06-18)
La protección del genoma viral durante el viaje extracelular es un requisito absoluto para la supervivencia y replicación del virus. Una vez que la partícula viral se une a la célula huésped, puede comenzar la eyección del ...
Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate
(2014-02-07)
Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any ...
The Golgi as an Assembly Line to the Autophagosome
(Elsevier, 2020-06)
Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles ...
Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis
(Nature, 2020-01-15)
The photoacoustic effect is generated when a variable light interacts with a strongly light-absorbing material. In water, it may produce hot bubbles and shock waves that could affect the integrity of nearby cellular ...
HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
(Public Library Science, 2014-07)
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism ...
The Myth of The Annular Lipids
(MDPI, 2022-10-22)
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the ...
Label-Free Monitoring of Tumor Models by Surface-Enhanced Raman Scattering
(2022-05-13)
El objetivo general de la presente tesis se ha centrado en la monitorización de modelos celulares mediante la técnica de espectroscopia de Raman aumentada en superficies (SERS). Las tecnologías desarrolladas en la tesis ...