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Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations
(BioMed Central, 2008-06)
Background: Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic ...
Actin- regulated Siglec- 1 nanoclustering influences HIV-1 capture and virus- containing compartment formation in dendritic cells
(eLife Sciences, 2023-03)
The immunoglobulin-like lectin receptor CD169 (Siglec-1) mediates the capture of
HIV- 1 by activated dendritic cells (DCs) through binding to sialylated ligands. These interactions
result in a more efficient virus capture ...
Novel Methodology for the Detection of Enveloped Viruses
(MDPI, 2020-06-15)
Viral infections in humans cause a huge burden in worldwide healthcare that has increased due to the emergence of new pathogenic viruses, such as in the recent Ebola virus (EBOV) outbreaks. Viral particles in body fluids ...
Structural study of flavivirus immunomodulator proteins from AEDES AEGYPTI salivary glands.
(2023-02-23)
Aedes aegypti bacteria-responsive protein 1 (AgBR1) y neutrophil stimulating factor 1 (NeSt1) son dos proteínas salivales del mosquito Aedes aegypti que actúan como potenciadoras de la infección del virus Zika (ZIKV). En ...
Molecular and biological consequences of targeting polyamine metabolism in prostate cancer
(2023-03-31)
The study of tumor metabolism has uncovered a new therapeutic window for the treatment of some cancer types. In such paradigm, cell signaling and metabolic reprogramming can act in tandem for the benefit of the cancer cell. ...
Understanding the role of CaMKIIa in Angelman Syndrome by looking at its potential interactors through proximity labelling
(2023-03-22)
El Síndrome de Angelman es una enfermedad rara que se caracteriza por la ausencia de la E3 ligasa de ubicuitina UBE3A en las neuronas. Numerosos datos sugieren una relación entre CAMKII y UBE3A. En esta tesis se emplea el ...
Identification of molecular mechanisms underlying frailty and successful aging in centenarians
(2023-03-31)
El envejecimiento es un proceso sistémico, multifactorial y degenerativo caracterizado por el declive y la pérdida de capacidades físicas y mentales. La esperanza media de vida ha aumentado considerablemente en el último ...
Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies
(National Academy of Sciences, 2022-10)
Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data suggest that smaller aggregates cause higher toxic response than filamentous aggregates (fibrils). However, the size of small aggregates ...
Cardiovascular Disease, Atherosclerosis and Familial Hypercholesterolemia: From Molecular Mechanisms Causing Pathogenicity to New Therapeutic Approaches
(MDPI, 2023-04-21)
This Special Issue, “Cardiovascular Disease, Atherosclerosis and Familial Hypercholesterolemia: From Molecular Mechanisms Causing Pathogenicity to New Therapeutic Approaches”, contributes to advancing our knowledge of the ...
Metabolism in the tumor cell and beyond
(Wiley, 2023-06)
The process of cellular transformation encompasses the acquisition of key and distinctive features, commonly known as hallmarks of cancer. These hallmarks are supported by tumor-intrinsic molecular alterations, as well as ...