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Interactome of the Autoimmune Risk Protein ANKRD55
(Frontiers Media, 2019-09-18)
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of ...
Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition
(MDPI, 2020-09-23)
Cardiovascular disease (CVD), the leading cause of mortality worldwide is primarily caused by atherosclerosis, which is promoted by the accumulation of low-density lipoproteins into the intima of large arteries. Multiple ...
Novel Transcript Discovery Expands the Repertoire of Pathologically-Associated, Long Non-Coding RNAs in Vascular Smooth Muscle Cells
(MDPI, 2021-02-02)
Vascular smooth muscle cells (VSMCs) provide vital contractile force within blood vessel walls, yet can also propagate cardiovascular pathologies through proliferative and pro-inflammatory activities. Such phenotypes are ...
BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque
(MDPI, 2020-12-09)
Carotid atherosclerotic plaque rupture can lead to cerebrovascular accident (CVA). By comparing RNA-Seq data from vascular smooth muscle cells (VSMC) extracted from carotid atheroma surgically excised from a group of ...
Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women
(Oxford University Press, 1994-08-01)
En esta interesante se describe la relación entre los niveles séricos de prolactina (PRL) basales y tras estimulación con hormona liberadora de tirotropina (TRH), y la composición proteica de la secreción del pezón en 54 ...
Functional organization of the HIV lipid envelope
(Nature, 2016-09-28)
The chemical composition of the human immunodeficiency virus type 1 (HIV-1) membrane is critical for fusion and entry into target cells, suggesting that preservation of a functional lipid bilayer organization may be required ...
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
(2017-01-13)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by ...
Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure
(Frontiers Media, 2018-09-04)
The envelope of Human Immunodeficiency Virus type 1 (HIV-1) consists of a liquid-ordered membrane enriched in raft lipids and containing the viral glycoproteins. Previous studies demonstrated that changes in viral membrane ...
Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering
(Wiley, 2021-02-21)
HIV-1 entry requires the redistribution of envelope glycoproteins (Env) into a cluster and the presence of cholesterol (chol) in the viral membrane. However, the molecular mechanisms underlying the specific role of chol ...
Structure-function of the alpha subunit of the human trimeric Gi3-protein (Gαi3)
(2023-12-15)
La tesis se centró en analizar el papel de las proteínas G, en particular GIV, en la señalización celular y su relevancia en enfermedades, como el cáncer metastásico. Se investigó un posible fármaco, IGGi-11, que se une a ...