Search
Now showing items 301-310 of 394
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
(MDPI, 2021-06-11)
Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ...
Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport
(Public Library of Science, 2015-06-19)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...
Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations
(Public Library of Science, 2011-03-10)
GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized ...
Cloning, purification and characterization of two components of phenol hydroxylase from Rhodococcus erythropolis UPV-1
(Springer, 2009-09-29)
Phenol hydroxylase that catalyzes the conversion of phenol to catechol in Rhodococcus erythropolis UPV-1 was identified as a two-component flavin-dependent monooxygenase. The two proteins are encoded by the genes pheA1 and ...
Effect of specific amino acid substitutions in the putative fusion peptide of structural glycoprotein E2 on Classical Swine Fever Virus replication
(Elsevier, 2014-05)
E2, along with Erns and E1, is an envelope glycoprotein of Classical Swine Fever Virus (CSFV). E2 is involved in several virus functions: cell attachment, host range susceptibility and virulence in natural hosts. Here we ...
Exploring the impact of transcriptional deregulation of cell communication related genes in prostate cancer
(2023-10-10)
El cáncer de próstata (CaP) es el segundo cáncer más frecuente en los hombres y ocupa el sexto lugar entre las causas de muerte relacionadas con el cáncer en todo el mundo. A pesar de las prometedoras respuestas clínicas ...
Characterization of environment-related endophenotypes in pulmonary hypertension
(2023-03-02)
La hipertensión pulmonar (HP) es una condición compleja caracterizada por un incremento de la presión en las arterias de los pulmones, que puede dañar el lado derecho del corazón. Clásicamente se define por unos valores ...
The importance of an integrated analysis of clinical, molecular, and functional data for the genetic diagnosis of familial hypercholesterolemia
(Nature, 2015-12)
Purpose
Familial hypercholesterolemia (FH) is one of the most common monogenic disorders, and the high concentrations of low-density lipoprotein (LDL) cholesterol presented since birth confers on these patients an increased ...
The allosteric control mechanisms of alpha-glucan biosynthesis in bacteria
(2023-10-03)
{EN]The alpha-glucans, polysaccharides made of repetitive units of glucose, play a role as energy storage, as with intracellular glycogen, or as structural components, as with the capsular alpha-glucans surrounding the ...