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Role of Mitochondrial Dynamics in Microglial Activation and Metabolic Switch
(American Association Of Immunologists, 2021-08-10)
Microglia act as sensors of injury in the brain, favoring its homeostasis. Their activation and polarization toward a proinflammatory phenotype are associated with injury and disease. These processes are linked to a metabolic ...
Functional and Metabolic Characterization of Microglia Culture in a Defined Medium
(Frontiers Media, 2020-02-07)
Microglia are the endogenous immune cells of the brain and act as sensor of infection and pathologic injury to the brain, leading to a rapid plastic process of activation that culminates in the endocytosis and phagocytosis ...
Neurotransmitter signaling in the pathophysiology of microglia
(Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
(Cell Press, 2020-03-27)
The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid ...
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum
(Nature Publishing Group, 2018-04)
The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic ...
Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus
(Elsevier, 2019-04-22)
The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. ...
Impact of parental mental illness in the attachment style of cluster B personality disorders
(2023-04-04)
[EN] Introduction: Cluster B personality disorders are the most controversial conditions in the psychopathological spectrum. Attachment seems to be a relevant factor in the development of these disorders. Emerging studies ...
Effects of the absence of TRPV1 in the expression of the cannabinoid 1 (CB1) receptor in the brain
(2023-04-05)
[EN] Though cannabinoids functions in the brain are typically associated with the activation of cannabinoid receptor 1 (CB1R), several effects depend on the activation of TRPV1, a receptor from the transient receptor ...
Mapping of plasticity and stress-related markers in acute and chronic stress in rats
(2023-04-05)
[EN] Stress is a physiological response to any kind of demand or threat that challenges the homeostasis of the organism. Although stress increases alertness and performance, excessive stress often negatively affects cognitive ...
Localization and Function of the Cannabinoid CB1 Receptor in the Anterolateral Bed Nucleus of the Stria Terminalis
(Public Library of Science, 2010-01-25)
Background: The bed nucleus of the stria terminalis (BNST) is involved in behaviors related to natural reward, drug addiction and stress. In spite of the emerging role of the endogenous cannabinoid (eCB) system in these ...