Search
Now showing items 301-310 of 410
Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine
(Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
(2018-05-04)
The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ...
Purinergic P2X4 receptors modulate neuroinflammation and repair in experimental multiple sclerosis
(2019-02-25)
La microglía examina el microambiente del sistema nervioso central para detectar señales de lesión o infección, y es esencial para el inicio y resolución de la inflamación inducida por patógenos o daño en los tejidos. ...
Synaptic dysfunction in Parkinson's Disease: functional and ultrastructural study of the striatal synapses in an animal model of progressive parkinsonism
(2021-02-26)
This Ph.D. project involves the temporal sequence of the earliest functional and structural events in the striatal synapses in a rat model of progressive parkinsonism induced by overexpression of human ¿-synuclein (h¿-syn) ...
High resolution imaging to unveil the subcellular layout of the cannabinoid type-1 receptor in rodent models of brain disease
(2020-02-28)
The present Thesis focuses on the description of new subcellular localizations of CB1 receptors in normal brain and the study of the CB1 receptor expression in certain pathophysiological states. Different histological ...
Signaling pathwais in oligodentdrocytes to promote myelin remodeling
(2022-03-16)
Oligodendrocytes make myelin and support axons metabolically with lactate. Experience and neuronal activity can induce dynamic changes in myelination during development and in adult life, suggesting a new form of plasticity ...
Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
(MDPI, 2021-02-09)
first_page
settings
Open AccessArticle
Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
by Diego Delgado
1, Ane Miren Bilbao
2, Maider Beitia
1, Ane ...
The Absence of the Transient Receptor Potential Vanilloid 1 Directly Impacts on the Expression and Localization of the Endocannabinoid System in the Mouse Hippocampus
(Frontiers Media, 2021-02-22)
The transient receptor potential vanilloid 1 (TRPV1) is a non-selective ligand-gated cation channel involved in synaptic transmission, plasticity, and brain pathology. In the hippocampal dentate gyrus, TRPV1 localizes to ...
In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke
(Ivyspring International Publisher, 2021)
Adenosine A(l) receptors (A(l)ARs) are promising imaging biomarkers and targets for the treatment of stroke. Nevertheless, the role of A(l)ARs on ischemic damage and its subsequent neuroinflammatory response has been ...
P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
(Frontiers Media, 2020-06-18)
Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and ...