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Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease
(Nature, 2024-01)
Retinal thickness may serve as a biomarker in Parkinson’s disease (PD). In this prospective longitudinal study, we aimed to determine if PD patients present accelerated thinning rate in the parafoveal ganglion cell-inner ...
Social cognition in myotonic dystrophy type 1: Specific or secondary impairment?
(Public Library Science, 2018-09-24)
Aims
The cognitive profile of Myotonic Dystrophy type 1 (DM1) has been described in recent decades. Moreover, DM1 patients show lowered social engagement and difficulties in social-cognitive functions. The aim of the ...
Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia
(Public Library Science, 2014-03-10)
Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated ...
Age‐related cognitive decline in myotonic dystrophy type 1: An 11‐year longitudinal follow‐up study
(Wiley, 2020-03)
Background Myotonic dystrophy type 1 (DM1) is an inherited multi-systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this ...
Evolution of pallial high-order sensory processing circuits.
(2024-01-12)
Understanding the appearance of the neocortex in evolution requires the study of its stereotyped sensory processing circuits andtheir formation during embryonic development. These circuits appear in sensory structures of ...
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
(Springer Nature, 2023)
Background
Cognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal layer thickness seems to be a good biomarker of cognition in other ...
Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
(Springer Nature, 2023)
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including ...
Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer’s Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms
(MDPI, 2024-04-23)
We compared the clinical and analytical performance of Alzheimer’s disease (AD) plasma biomarkers measured using the single-molecule array (Simoa) and Lumipulse platforms. We quantified the plasma levels of amyloid beta ...
Endocannabinoid modulation of astroglial cells in multiple sclerosis
(2022-05-16)
El objetivo global de esta Tesis Doctoral es ampliar el conocimiento actual sobre el papel del sistema endocannabinoide en la modulación de los astrocitos en la EM, con especial énfasis en los CB1Rs astrogliales. Nuestros ...
Exploring pro-resolution mediator ATL and complement receptor CR3 as potential therapeutic targets for Alzheimer's disease
(2022-05-06)
La enfermedad de Alzheimer (EA) es la causa más común de demencia. Sus principales características histopatológicas son las placas de amiloide ß (Aß) y los ovillos neurofibrilares de tau. La producción y agregación excesivas ...