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Characterization and pharmacological modulation of calcium handling proteins in Limb-Girdle Muscle Dystrophy type R1
(2021-01-27)
Limb-girdle muscle dystrophy type R1 (LGMDR1) is the most common form of limb-girdle muscle dystrophy, currently with no effective treatment. LGMDR1 is caused by mutations in the CAPN3 gene and is characterized by reduced ...
Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment
(Wolters Kluwer Health, 2022-12)
Background:Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol ...
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
(BMC, 2022-12)
Antisense oligonucleotide (ASO) therapy for neurological disease has been successful in clinical settings and its potential has generated hope for Alzheimer's disease (AD). We previously described that ablating SNCA encoding ...
Exploring microglial targets in experimental multiple sclerosis
(2022-06-30)
La esclerosis múltiple (EM) es una enfermedad crónica e inflamatoria del sistema nervioso central, que provoca desmielinización y degeneración axonal. Por su parte, la microglía es la célula inmune residente en el sistema ...
Unraveling the role of astrocytes in the onset and spread of Parkinson's Disease: Important contributors to neurodegeneration.
(2020-02-28)
La enfermedad de Parkinson (EP) se caracteriza principalmente por la presencia de inclusiones citoplasmáticas llamadas cuerpos de Lewy, cuyo principal componente es la ¿-sinucleína y la pérdida de neuronas dopaminérgicas ...
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
(MDPI, 2021-06-02)
Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, ...
Microglial phagocytosis form development to neurodegenerative diseases
(2021-09-30)
a microglía es el macrófago residente del sistema nervioso central (SNC). Estos centinelas cerebrales "escanean" continuamente el parénquima cerebral con sus procesos delgados, largos y ramificados que ayudan a mantener ...
Cross-Validation of Predictive Equation for Cardiorespiratory Fitness by Modified Shuttle Walk Test in Adults with Schizophrenia: A Secondary Analysis of the CORTEX-SP Study
(MDPI, 2021-10-29)
Cardiorespiratory fitness (CRF) can be direct or estimated from different field tests. The Modified Shuttle Walk Test (MSWT) is suitable for all levels of function, allowing a peak response to be elicited. Therefore, we ...
Neurocognitive, social cognitive, and clinical predictors of creativity in schizophrenia
(Pergamon-Elsevier, 2020-10)
Background: Creativity is considered an essential human accomplishment and a key component for daily life problem solving. It has been suggested that impairment in working memory, cognitive flexibility, and theory of mind ...
The impact of creativity on functional outcome in schizophrenia: a mediational model
(Springer, 2021-02-26)
Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively ...