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Now showing items 2061-2070 of 2079
Exploring ‘minimal metabolism’ as a central concept for understanding the origins of life and developing systems biology
(2023-09-29)
Origins of life (OL) research, as the name suggests, is concerned with the question of how cellular organisms could have develop, starting from complex chemical reaction systems, i.e.the transition from geo-chemistry to ...
Unveiling Pathophysiological Mechanisms and Early Transcriptomic Biomarkers in Hereditary Progranulin-Related Frontotemporal Dementia: A Comprehensive Study
(2024-03-22)
[EN]Frontotemporal dementia (FTD) is a neurodegenerative disorder and the second leading cause of dementia, affecting patients in behavior and language capabilities under 65 years old. Despite ongoing progress, there are ...
Identification of novel drivers of cancer malignancy
(2024-03-11)
[EN]SRY-box transcription factor 9 (SOX9) is a critical developmental regulator that guides cell-fate decisions and maintenance of stem cells during development and adult homeostasis in a wide range of tissues, including ...
Proteostasis regulation of the centrosomal protein LUZP1, a mediator of Townes-Brocks Syndrome
(2024-03-18)
ownes-Brocks Syndrome (TBS) is a rare autosomal dominant genetic disorderlinked to SALL1 gene mutations (SALL1MUT), affecting 1 in 250,000 live births. Itmanifests with distinctive features like dysplastic ears, preaxial ...
Mapping the diversity of trained immunity against live bacteria: plasticity of macrophage response in homeostasis and disease
(2024-03-21)
In the past decade, the existence of long-term consequences of the stimulation of innate immune cells has been recognized, resulting in divergent immune responses to secondary challenges. Trained immunity has redefined our ...
Psychobiological Characterization of Resilience: Study of the Effectiveness of a Peer Support Intervention in Breast Cancer Patients
(2024-04-09)
[EN]As breast cancer (BC) continues to be a leading cause of death among women worldwide, understanding the factors contributing to disease adjustment is essential. Psychological resilience, defined as the ability to ...
Angular Margin-Based Softmax Losses: Toward Discriminative Deep Metric Learning
(2024-04-25)
Discriminative deep metric learning aims to construct an embedding space in whichinstances of the same class can be grouped together while being effectivelydistinguished from instances belonging to other classes by deeply ...
In vitro evaluation of liposomes tailored for non-invasive delivery of the model antigen ovalbumin to skin, nose, and lungs
(2024-04-05)
Vaccination stands out as the most potent and successful preventive measure ever devised to safeguard individuals worldwide from life-threatening diseases. It contributes not only to individual protection but also to ...
Theoretical Design of CO Poisoning Resistant Pt Catalysts through Ge Alloying
(2024-03-01)
The rapid growth of population over the last decades has supposed a vast increment in the consumption of fossil fuels to meet our energy demands. This overconsumption has accelerated the emission of greenhouse gases, ...
Development, implementation and applications of hybrid quantum chemistry models
(2024-03-15)
The field of theoretical quantum chemistry aims to organize chemical laws, principles and rules by applying quantum mechanics to various challenges within the real of chemistry. Central to this framework is the interconnection ...