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Now showing items 14761-14770 of 15072
Genetic Variants in MiRNA Processing Genes and Pre-MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia
(Public Library Science, 2015-03-20)
Genome wide association studies (GWAS) have identified several low-penetrance susceptibility alleles in chronic lymphocytic leukemia (CLL). Nevertheless, these studies scarcely study regions that are implicated in non-coding ...
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
(Dove Medical Press, 2017-03-27)
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ...
Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia
(Public Library Science, 2014-03-10)
Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated ...
Is Social Media a New Type of Social Support? Social Media Use in Spain during the COVID-19 Pandemic: A Mixed Methods Study
(MDPI, 2022-03-26)
This study examines Spanish adults’ social media use during the COVID-19 pandemic using mixed-methods to assess and understand frequency, context, and changes in social media use during two critical time points in Spain. ...
Teachers’ knowledge of ADHD: relevance of training and individual perceptions
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2016)
El presente estudio analiza el conocimiento que los maestros presentan sobre el TDAH y su relación con diversas variables formativas y auto-perceptivas. La muestra estuvo compuesta por 1278 docentes de 108 centros escolares. ...
The Emotional Divergent–Convergent Thinking Program (EDICOP): Design, Implementation, and Results
(MDPI, 2020-11-13)
In a social environment that requires young people to adapt to increasingly demanding situations, emotional education and creativity training may be key for both personal development and academic performance. Given that ...
Age‐related cognitive decline in myotonic dystrophy type 1: An 11‐year longitudinal follow‐up study
(Wiley, 2020-03)
Background Myotonic dystrophy type 1 (DM1) is an inherited multi-systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this ...
Lipid regulation of Atg8 family protein recruitment and membrane modulation of mitophagy and autophagic cell death
(2017-01-20)
Tesi lan honen aurkikuntzek, mitofagian zehar LC3/GABARAP familiako proteinen mitokondrioetarako errekrutatze-prozesuaren mekanismo molekularraren eta Atg8 proteinaren giza ortologoek giza lerro zelular ezberdinetan daukaten ...
Genetic variants involved in Childhood Acute Lymphoblastic Leukemia Susceptibility
(2016-12-15)
La Leucemia linfoblástica aguda (LLA) infantil es el cáncer pediátrico más común. El hecho de que se desarrolle a una edad temprana sugiere que para su aparición debe existir un fuerte componente genético. Recientes GWAS ...
The Sailor diagram – A new diagram for the verification of two-dimensional vector data from multiple models
(Copernicus Gesellschaft, 2020-07-15)
A new diagram is proposed for the verification of vector quantities generated by multiple models against a set of observations. It has been designed with the objective, as in the Taylor diagram, of providing a visual ...