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Now showing items 14791-14800 of 15516
Distinct mechanisms of lipid bilayer perturbation induced by peptides derived from the membrane-proximal external region of HIV-1 gp41
(ACS Publications, 2009-04-29)
The conserved, membrane-proximal external region (MPER) of the human immunodeficiency
virus type-1 envelope glycoprotein 41 subunit is required for fusogenic activity. It has been proposed that
MPER functions by disrupting ...
The three lives of viral fusion peptides
(Elsevier, 2014-04)
Fusion peptides comprise conserved hydrophobic domains absolutely required for the fusogenic activity of glycoproteins from divergent virus families. After 30 years of intensive research efforts, the structures and functions ...
Molecular Recognition of the Native HIV-1 MPER Revealed by STED Microscopy of Single Virions
(Springer, 2019-01-08)
Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on the MPER native structure and accessibility, ...
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
(Nature, 2022)
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...
Cholesterol Constrains the Antigenic Configuration of the Membrane-Proximal Neutralizing HIV-1 Epitope
(ACS, 2020-06-25)
The envelope glycoprotein (Env) enables HIV-1 cell entry through fusion of host-cell and viral membranes induced by the transmembrane subunit gp41. Antibodies targeting the C-terminal sequence of the membrane-proximal ...
Functional Delineation of a Protein–Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8
(MDPI, 2022-09-15)
Antibody engagement with the membrane-proximal external region (MPER) of the envelope glycoprotein (Env) of HIV-1 constitutes a distinctive molecular recognition phenomenon, the full appreciation of which is crucial for ...
Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface
(Springer Nature, 2016-12-01)
The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and ...
Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids
(Elsevier, 2010-03-17)
The broadly neutralizing anti-HIV-1 2F5 monoclonal antibody recognizes a gp41 epitope proximal to the viral membrane. Potential phospholipid autoreactivity at cell surfaces has raised concerns about the use of this antibody ...
IV International Forum on Cooperative Law. Cooperation among cooperatives: a principle of the past or for the future?
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2024)
Aurkibidea / Índice / Index:
- Taxation of Cooperation Processes Among Cooperatives in Spain (Marina Aguilar Rubio).
- Notes on the Taxation of Co-Operatives General Issues and Concepts (Dr. Ann App).
- Kooperatiben ...