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On the Selection of Non-Invasive Methods Based on Speech Analysis Oriented to Automatic Alzheimer Disease Diagnosis
(MDPI, 2013-05)
The work presented here is part of a larger study to identify novel technologies and biomarkers for early Alzheimer disease (AD) detection and it focuses on evaluating the suitability of a new approach for early AD diagnosis ...
Framework for the Shape Optimization of Aerodynamic Profiles Using Genetic Algorithms
(Hindawi Publishing Corporation, 2013)
This study developed a framework for the shape optimization of aerodynamics profiles using computational fluid dynamics (CFD) and genetic algorithms. Agenetic algorithm code and a commercial CFD code were integrated to ...
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
(Cell Press, 2018-04-19)
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...
Identification and Monitoring of Parkinson's Disease Dysgraphia Based on Fractional-Order Derivatives of Online Handwriting
(MDPI, 2018-12-11)
Parkinson's disease dysgraphia affects the majority of Parkinson's disease (PD) patients and is the result of handwriting abnormalities mainly caused by motor dysfunctions. Several effective approaches to quantitative PD ...
Novel Biobased Polyamide 410/Polyamide 6/CNT Nanocomposites
(MDPI, 2018-09)
Biobased polyamide 410 (PA410)/multiwall carbon nanotube (CNT) nanocomposites (NCs) were obtained by melt-mixing in a twin screw extruder a Polyamide 6 (PA6)-based masterbatch (with 15 wt % CNT content) with neat PA410. ...
Historic Urban Landscapes: A Review on Trends and Methodologies in the Urban Context of the 21st Century
(MDPI, 2018-08)
This article makes a critical reflection, questioning the notion of historical urban landscapes as a conceptual paradigm used for the basis of urban conservation in the twenty-first century. The study begins with a brief ...
Glycans in drug discovery
(Royal Soc Chemistry, 2019-07-26)
Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically ...
Human DenPulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain
(Frontiers Media, 2019-03-28)
Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult ...
Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
(MDPI, 2019-03-01)
Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ...
The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases
(Public Library Science, 2016-12-29)
Clear cell renal cell carcinoma (CCRCC) is a heterogeneous and complex disease that frequently develops distant metastases. Fibroblast activation protein (FAP) is a serine peptidase the expression of which in cancer-associated ...