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Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma
(BMC, 2019-12-14)
Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ...
Glycan structures and their interactions with proteins. A NMR view
(Elsevier, 2019-12)
Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ...
Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
(American Chemical Society, 2019-08-28)
The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important anchor point for our immune system to act against streptococcal infections. Antibodies can recognize Sp1 saccharides, and it has ...
A Methodology to Evaluate the Reliability Impact of the Replacement of Welded Components by Additive Manufacturing Spare Parts
(MDPI, 2019-08-26)
This article shows a method for inspection scheduling of structures made by additive manufacturing, derived from reliability function evaluations and overhaul inspection findings. The routine was an adaption of an existing ...
Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial
(Biomed Central, 2017-08-10)
Background: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention ...
Genetics of Type III Bartter Syndrome in Spain, Proposed Diagnostic Algorithm
(Public Library of Science, 2013-09-18)
The p.Ala204Thr mutation (exon 7) of the CLCNKB gene is a "founder" mutation that causes most of type III Bartter syndrome cases in Spain. We performed genetic analysis of the CLCNKB gene, which encodes for the chloride ...
Changes in white adipose tissue metabolism induced by resveratrol in rats
(BioMed Central, 2011-05)
Background: A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the ...
Efficient implementation of symplectic implicit Runge-Kutta schemes with simplified Newton iterations
(2017-03-30)
We are concerned with the efficient implementation of symplectic
implicit Runge-Kutta (IRK) methods applied to systems of (non-necessarily
Hamiltonian) ordinary differential equations by means of Newton-like iterations. ...
Reducing and monitoring round-off error propagation for symplectic implicit Runge-Kutta schemes
(2017-01-31)
We propose an implementation of symplectic implicit Runge-Kutta schemes for highly accurate numerical integration of non-stiff Hamiltonian systems based on fixed point iteration. Provided that the computations are done in ...
Measuring The Economic Impact Of Farmers' Markets On Local Economies In The Basque Country
(MDPI, 2018-01-08)
Farmers' markets are a traditional exchange space for local peasants, around which alternative agri-food networks (AFNs) are being built on a local scale. These AFNs seek to establish quality and trust-based equitable ...