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Replacement of Cysteine at Position 46 in the First Cysteine-Rich Repeat of the LDL Receptor
(Public Library Science, 2018-10-17)
Background and aims
Pathogenic mutations in the Low Density Lipoprotein Receptor gene (LDLR) cause Familial Hypercholesterolemia (FH), one of the most common genetic disorders with a prevalence as high as 1 in 200 in ...
Three Dimensional Nanoscale Analysis Reveals Aperiodic Mesopores in a Covalent Organic Framework and Conjugated Microporous Polymer
(Royal Society of Chemistry, 2019-02-14)
The integrated analytical approach developed in this study offers a powerful methodology for the structural characterisation of complex molecular nanomaterials. Structures of a covalent organic framework based on boronate ...
Familial amyloidosis with polyneuropathy type 1 caused by transthyretin mutation Val50Met (Val30Met): 4 cases in a non-endemic area
(Elsevier, 2018-11)
Introduction: Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) typically arises as an autonomic neuropathy primarily affecting small fibres and it occurs in adult patients in their second or third decades ...
Ionic Hydrogel for Accelerated Dopamine Delivery via Retrodialysis
(American Chemical Society, 2019-07-29)
Local drug delivery directly to the source of a given pathology using retrodialysis is a promising approach to treating otherwise untreatable diseases. As the primary material component in retrodialysis, the semipermeable ...
Elite Swimmers’ Training Patterns in the 25 Weeks Prior to Their Season’s Best Performances: Insights Into Periodization From a 20-Years Cohort
(Frontiers Media, 2019-04-10)
Background: This study investigated the periodization of elite swimmers' training over the 25 weeks preceding the major competition of the season.
Methods: We conducted a retrospective observational study of elite male ...
GqqA, a Novel Protein in Komagataeibacter Europaeus Involved in Bacterial Quorum Quenching and Cellulose Formation
(Biomed Central, 2016-05-24)
Background: We report on the functional screening and identification of an active quorum quenching (QQ) gene in the Komagataeibacter europaeus strain CECT 8546, which is a member of the acetic acid bacteria (AAB).
Results: ...
Training and Competition Readiness in Triathlon
(MDPI, 2019-04-29)
Triathlon is characterized by the multidisciplinary nature of the sport where swimming, cycling, and running are completed sequentially in different events, such as the sprint, Olympic, long-distance, and Ironman formats. ...
Raman imaging to quantify the thermal transformation degree of Pompeian yellow ochre caused by the 79 AD Mount Vesuvius eruption
(Springer, 2019-11-07)
Most of the wall paintings from Pompeii are decorated with red and yellow colors but the thermal impact of 79 AD MountVesuvius eruption promoted the partial transformation of some yellow-painted areas into red. The aim of ...
The Complex Phosphorylation Patterns That Regulate the Activity of Hsp70 and Its Cochaperones
(MDPI, 2019-08-23)
Proteins must fold into their native structure and maintain it during their lifespan to display the desired activity. To ensure proper folding and stability, and avoid generation of misfolded conformations that can be ...
Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
(Nature Publishing, 2019-09-11)
The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells ...