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MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
(Dove Medical Press, 2017-03-27)
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ...
Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia
(Public Library Science, 2014-03-10)
Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated ...
Teachers’ knowledge of ADHD: relevance of training and individual perceptions
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2016)
El presente estudio analiza el conocimiento que los maestros presentan sobre el TDAH y su relación con diversas variables formativas y auto-perceptivas. La muestra estuvo compuesta por 1278 docentes de 108 centros escolares. ...
A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
(Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ...
Combining random forests and physics-based models to forecast the electricity generated by ocean waves: A case study of the Mutriku wave farm
(Pergamon-Elsevier, 2019-10-01)
This paper combines random forests with physics-based models to forecast the electricity output of the Mutriku wave farm on the Bay of Biscay. The period analysed was 2014-2016, and the forecast horizon was 24 h in 4-h ...
Global estimations of wind energy potential considering seasonal air density changes
(Pergamon-Elsevier, 2019-11-15)
The literature typically considers constant annual average air density when computing the wind energy potential of a given location. In this work, the recent reanalysis ERA5 is used to obtain global seasonal estimates of ...
Cohomology of p-groups of nilpotency class smaller than p
(De Gruyter, 2018-01-17)
Let p be a prime number, let d be an integer and let G be a d-generated finite p-group of nilpotency class smaller than p. Then the number of possible isomorphism types for the mod p cohomology algebra H^∗(G;F_p) is bounded ...
Genetic turnovers and northern survival during the last glacial maximum in European brown bears
(John Wiley & Sons, 2019-05-29)
The current phylogeographic pattern of European brown bears (Ursus arctos) has
commonly been explained by postglacial recolonization out of geographically distinct
refugia in southern Europe, a pattern well in accordance ...
Middle Pleistocene protein sequences from the rhinoceros genus Stephanorhinus and the phylogeny of extant and extinct Middle/Late Pleistocene Rhinocerotidae
(PeerJ Inc., 2017-03-14)
Ancient protein sequences are increasingly used to elucidate the
phylogenetic relationships between extinct and extant mammalian taxa. Here, we
apply these recent developments to Middle Pleistocene bone specimens of ...
Shell midden people in northern Iberia. New data from the mesolithic rock shelter of J3 (Basque Country, Spain)
(Ediciones Universidad de Salamanca, 2010)
[EN]In the course of a sondage dug in the rock shelter of J3, in the Jaizkibel mountains (at the north-western tip of Guipúzcoa), the body of a adult man was located buried inside a shell midden. This shell midden had not ...