Search
Now showing items 51-60 of 74
Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction
(Nature Research, 2022)
[EN] Inflammatory bowel disease (IBD) is characterised by chronic inflammation of the gastrointestinal tract. Although its aetiology remains unknown, environmental and genetic factors are involved in its development. ...
Adiponectin, leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD
(Frontiers Media, 2021-06-23)
[EN] Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease where liver biopsy remains the gold standard for diagnosis. Here we aimed
to evaluate the role of circulating adiponectin, ...
Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country
(MDPI, 2020)
Epidemiologic studies have revealed inconsistent evidence of gene-diet interaction in
relation to colorectal cancer (CRC). The aim of this study was to analyze them in a sample of cases and
controls from the population-based ...
Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population
(Public Library Science, 2019-12-10)
Given the significant population diversity in genetic variation, we aimed to investigate whether single nucleotide polymorphisms (SNPs) previously identified in studies of colorectal cancer (CRC) susceptibility were also ...
Food groups, diet quality and colorectal cancer risk in the Basque Country
(Baishideng Publishing Group Inc, 2020-07-28)
BACKGROUND
The results obtained to date concerning food groups, diet quality and colorectal
cancer (CRC) risk vary according to criteria used and the study populations.
AIM
To study the relationships between food groups, ...
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
(Wiley, 2020-09-22)
Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver ...
Analysis of Post-Colonoscopy Colorectal Cancer and Its Subtypes in a Screening Programme
(MDPI, 2021-10-12)
Using the algorithm of the World Endoscopy Organisation (WEO), we have studied retrospectively all colorectal cancers, both detected and non-detected by the Basque Country screening programme from 2009 to 2017. In the ...
TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation
(Elsevier, 2022-10)
Background & Aims: Inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central to cholestatic liver injury. The triggering ...
Extracellular Vesicles in Hepatobiliary Malignancies
(Frontiers Media, 2018-10-12)
Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly ...
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
(Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ...