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Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia
(Springer Nature, 2014-11-04)
Methotrexate (MTX) is an effective and toxic chemotherapeutic drug in the treatment of pediatric acute lymphoblastic leukemia(ALL). In this prospective study, we aimed to identify metabolic and genetic determinants of MTX ...
Linguistic Accessibility for Small Language Cinema
(IGI Global, 2016)
Audiovisual accessibility is considered as a basic right. In a world where audiovisual material is more and more present, several measures have been taken in order to facilitate the access to it by people living with sensory ...
Potential relationship between single nucleotide polymorphisms used in forensic genetics and diseases or other traits in European population
(Springer, 2015-03-13)
Single nucleotide polymorphisms (SNPs) are an interesting option to facilitate the analysis of highly degraded DNA by allowing the reduction of the size of the DNA amplicons. The SNPforID 52-plex panel is a clear example ...
Animal-assisted psychotherapy for young people with behavioural problems in residential care
(Wiley, 2017)
The aim of this study was to evaluate the impact of an animal-assisted psychotherapy (AAP) programme on clinical symptoms, personal adjustment and adaptive skills in a group of adolescents in residential care who had ...
Promoting psychosocial adaptation of youths in residential care through animal-assisted psychotherapy
(Elsevier, 2015-10-09)
The goal of this study was to examine the influence of animal-assisted psychotherapy (AAP) on the psychosocial adaptation of a group of adolescents in residential care who had suffered traumatic childhood experiences and ...
Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
(Springer Nature, 2017-01-18)
The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's ...
Influence of Animal-Assisted Therapy (AAT) on the Attachment Representations of Youth in Residential Care
(Elsevier, 2014-04-18)
This study evaluates the influence of Animal-Assisted Therapy (AAT) on the attachment representations of a group of adolescents in residential care who suffered traumatic childhood experiences and exhibited mental health ...
Genetic Variants in MiRNA Processing Genes and Pre-MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia
(Public Library Science, 2015-03-20)
Genome wide association studies (GWAS) have identified several low-penetrance susceptibility alleles in chronic lymphocytic leukemia (CLL). Nevertheless, these studies scarcely study regions that are implicated in non-coding ...
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
(Dove Medical Press, 2017-03-27)
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ...
Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia
(Public Library Science, 2014-03-10)
Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated ...