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Conjugative Coupling Proteins and the Role of Their Domains in Conjugation, Secondary Structure and in vivo Subcellular Location
(Frontiers Media, 2020-08-11)
Type IV Coupling Proteins (T4CPs) are essential elements in many type IV secretion systems (T4SSs). The members of this family display sequence, length, and domain architecture heterogeneity, being the conserved ...
Extension and improvement of synchronous linear generator based point absorber operation in high wave excitation scenarios
(Elsevier, 2021-11-01)
[EN]The exploitation of marine wave energy resource has led to the design of numerous Wave Energy Converter (WEC) configurations. The power absorption of a WEC is tightly related to its physical properties and the ...
Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase
(MDPI, 2021-11-30)
The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this protein, the toxicity of its aggregation intermediates and the ...
Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review
(Elsevier, 2021-09)
Diffuse large B-cell lymphoma (DLBCL), the most common type of Non-Hodgkin lymphoma (NHL), is a highly heterogeneous and aggressive disease. Regardless of this heterogeneity, all patients receive the same first-line therapy, ...
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group
(Elsevier, 2022-02)
[EN] BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. Comparison of incidence of allergic reactions to pegylated ...
Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study
(Wiley, 2022-06)
[EN] Background White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome ...
Submerged and reused: An archaeometric approach to the early Modern ceramics from Aveiro (Portugal)
(2020-11-02)
Aveiro, a city located in northern Portugal that lies next to the Atlantic Ocean, has a long potting tradition.
Indeed, during the 15th–17th centuries, this region played an important role in the maritime trade between ...
What Are the Best Practices to Foster Students’ Motivation in Multilingual Schools? The Teachers’ Perspective
(Macrothink Institute, 2023-10-20)
This contribution focusses on teachers’ perspectives on ways of motivating students in multilingual education settings where a local minority language co-exists with a State majority language, English as a lingua franca ...
Symmetric fluxes and small tadpoles
(Springer Nature, 2023-08-04)
The analysis of type IIB flux vacua on warped Calabi-Yau orientifolds becomes considerably involved for a large number of complex structure fields. We however show that, for a quadratic flux superpotential, one can devise ...
Comprehensive micropollutant characterization of wastewater during Covid-19 crisis in 2020: Suspect screening and environmental risk prioritization strategy
(Elsevier, 2023-05)
Micropollutants monitoring in wastewater can serve as a picture of what is consuming society and how it can impact the aquatic environment. In this work, a suspect screening approach was used to detect the known and unknown ...