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Now showing items 11-20 of 36
Estudio de la expresión de micrornas y su modulacion como potencial diana terapéutica en la retinosis pigmentaria
(2018-06-07)
La retinosis pigmentaria (RP) es la principal causa genética de degeneración de la visión en todo el mundo con más de 1.5 millones de afectados, para la que aún no existe un tratamiento estandarizado y eficaz. Esta enfermedad ...
Learning and memory improvement mediated by CB1 cannabinoid receptors in animal models of cholinergic dysfunction
(2018-10-26)
The selective vulnerability of the basal forebrain cholinergic system (BFCS) is responsible for most of the clinical alterations in learning and memory processes that are characteristic of the Alzheimer¿s disease (AD). The ...
Biochemical and functional charactrization of the CB1 cannabinoid recptor coupling to Gai/l proteins in synaptosomal membranes from hippocampus and frontal cortex of cell-type-specifc mutant mouse rescue model
(2021-05-18)
Egun, ezaguna da terminal sinaptiko glutamatergiko eta GABAergikoetan espresatzen den CB1 hartzailearen aktibazioak aktibitate neuronal eszitatzaile-inhibitzailearen balantzea erregulatzen duela. Horregatik, bi terminal ...
Determining the binding kinetics and signalling effects of CB1 and CB2 receptor ligands; a closer look at residence time and functional selectivity
(2022-05-30)
The CB1 and CB2 receptors are the main GPCRs of the endocannabinoid system, and regulate many important physiological processed as pain, inflammation, or behaviour. Increasing interest exist to develop new drugs targeting ...
Role of G protein coupled inwardly rectifier K+ channels (GIRK) on the neurobiology depression
(2014-02-11)
[EN] Major depression is a recurrent or chronic mood disorder with impaired psychosocial function, and an increased tendency of relapse for patients who fail to reach remission. In industrialized societies, it affects 15% ...
Molecular mechanisms underlying cannabis abuse and schizophrenia: Focus on 5-HT2A receptors and Akt/mTOR signaling pathway
(2020-07-09)
Schizophrenia is a chronic and disabling mental illness that affects around 20 million people worldwide. The etiology of the disorder is multifactorial, and different genetic and environmental factors take part in its onset ...
Tailored gelatin-based three-dimensional sysems for bone tissue engineering.
(2019-12-17)
The current Doctoral Thesis is focused on the development of three-dimensional systems for bone tissue engineering purposes. Gelatin was chosen as the main material to manufacture scaffolds capable for serving as both ...
Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
(2019-12-02)
Schizophrenia is a multi multifaceted, heterogeneous, chronic and debilitating disorder triggered by a series of interacting genetic, developmental and environmental factors. Cognitive impairment is considered a core feature ...
Effect of novel ryanodine receptor modulators in mouse and human models of Duchenne muscular dystrophy
(2017-05-31)
La distrofia muscular de Duchenne (DMD) es una enfermedad hereditaria ligada al cromosoma X queafecta a uno de cada 3500 varones. Esta enfermedad se caracteriza por la degeneración progresiva de lasfibras musculares que ...
Neurophysiology of non-motor complications in Parkinson's disease: role of the locus coeruleus.
(2020-05-08)
La enfermedad de Parkinson es un trastorno neurodegenerativo, definido inicialmente por sus síntomas motores. Sin embargo, hoy en día la probabilidad de que se trate de un trastorno complejo en lugar de una enfermedad ...