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Combining imaging mass spectrometry and immunohistochemistry to analyse the lipidome of spinal cord inflammation
(Springer Nature, 2024-02)
Inflammation is a complex process that accompanies many pathologies. Actually, dysregulation of the inflammatory process is behind many autoimmune diseases. Thus, treatment of such pathologies may benefit from in-depth ...
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif
(Nature, 2024-01)
The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial and peroxisomal fission, but the regulatory mechanisms remain ambiguous. Here we find that a conserved, intrinsically disordered, six-residue ...
Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
(Nature, 2024-02)
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2R and mGlu3R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3R ligands in clinical trials. ...
High-throughput virtual search of small molecules for controlling the mechanical stability of human CD4
(Elsevier, 2024-04)
Protein mechanical stability determines the function of a myriad of proteins, especially proteins from the extracellular matrix. Failure to maintain protein mechanical stability may result in diseases and disorders such ...
Constrained trait variation by water availability modulates radial growth in evergreen and deciduous Mediterranean oaks
(Elsevier, 2024-03)
Spatial and temporal variation in functional traits allows trees to adjust to shifting environmental conditions such as water stress. However, the change of traits, both mean and variances, along water availability gradients ...
Eutectogels as a Semisolid Electrolyte for Organic Electrochemical Transistors
(ACS, 2024-02)
Organic electrochemical transistors (OECTs) are signal transducers offering high amplification, which makes them particularly advantageous for detecting weak biological signals. While OECTs typically operate with aqueous ...
Areas of interest and sentiment analysis towards second generation antipsychotics, lithium and mood stabilizing anticonvulsants: Unsupervised analysis using Twitter
(Elsevier, 2024-04)
Background
Severe mental disorders like Schizophrenia and related psychotic disorders (SRD) or Bipolar Disorder (BD) require pharmacological treatment for relapse prevention and quality of life improvement. Yet, treatment ...
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
(Elsevier, 2024-05)
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a crucial window for potential therapeutic ...
Transformer-based fall detection in videos
(Elsevier, 2024-06)
Falls pose a major threat for the elderly as they result in severe consequences for their physical and mental health or even death in the worst-case scenario. Nonetheless, the impact of falls can be alleviated with appropriate ...
Anti-Candida Antibodies of Patients with Invasive Candidiasis Inhibit Growth, Alter Cell Wall Structure, and Kill Candida albicans In Vitro
(Springer Nature, 2024)
Invasive candidiasis (IC), caused by Candida yeasts, particularly Candida albicans, poses a significant threat with high mortality rates. Diagnosis is challenging due to Candida's common presence in human microbiota. To ...