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Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
(SpringerNature, 2022)
[EN] Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying ...
Genetically modified macrophages accelerate myelin repair
(Wiley, 2022-08-08)
[EN] Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in ...
Clemastine Induces an Impairment in Developmental Myelination
(Frontiers Media, 2022)
[EN] Abnormalities in myelination are associated to behavioral and cognitive dysfunction in neurodevelopmental psychiatric disorders. Thus, therapies to promote or accelerate myelination could potentially ameliorate symptoms ...
Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain
(Wiley, 2021-10)
Background and purpose Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional ...