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Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
(Nature, 2023-06)
Originally considered to act as a transcriptional co‑factor, Pirin has recently been reported to play a
role in tumorigenesis and the malignant progression of many tumors. Here, we have analyzed the
diagnostic and ...
RKIP Regulates Differentiation-Related Features in Melanocytic Cells
(MDPI, 2020-06-03)
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of keysignaling pathways involved in the aggressive tumor phenotype and shows decreased expressionin several types of cancers. However, ...
Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells
(MDPI, 2020-03-07)
Dental pulp stem cells (DPSCs) from adult teeth show the expression of a very complete repertoire of stem pluripotency core factors and a high plasticity for cell reprogramming. Canonical Wnt and Notch signaling pathways ...
The Multifunctional Role of SPANX-A/D Protein Subfamily in the Promotion of Pro-Tumoural Processes in Human Melanoma
(Nature, 2021-02-11)
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various ...