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Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative to radioligand binding methods
(BMC, 2022)
Background: Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards ...
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
(Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ...
Neuromarketina: kontsumitzaileon garunaren barruan
(Elhuyar, 2012-05-01)
Zer nahiago duzu? Pepsi ala Coca-Cola? McDonald´s ala Burger King? Apple ala Microsoft? Mercedes ala Golf? Pentsatu al duzu inoiz norberaren gogoak eta nahiak zertan oinarrituta dauden? Zerk bultzatzen gaitu hori erostera? ...
Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain
(Elsevier, 2012-10-11)
The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ...
Ispilu bizidunak gara: Ispilu-neuronek besteen larruan jartzen gaituzte
(Elhuyar, 2010-06)
Imajinatu zirko-ikuskizun bat ikusten ari zarela. Bat-batean, trapezioan dagoen akrobata irristatu egiten da eta oreka galtzen du… bihotza uzkurtu egin zaizu! Eztarrian korapilo bat duzu eta taupadak bizkortu egin zaizkizu. ...
Plastikotasun neuronala: garunaren zaindari
(Elhuyar, 2011-04-01)
Denbora luzez pentsatu da garuneko lesio baten ondorioz neuronak betirako galtzen zirela eta, heldutasunera behin helduta, burmuinaren garapena eten egiten zela. Azken hamarkadetan, berriz, argi geratu da garunak malgutasuna ...
Plazeraren oinarri neurobiologikoak: sari-sistema zerebrala
(Elhuyar, 2013-07-01)
Sari-sistema edo bide mesokortikolinbiko dopaminergiko deritzana plazerarekin erlazionatuta dagoen sare neuronal bat da.Sistema horren aurkikuntza oso garrantzitsua izan da neurozientzia eta psikologia arloan. Lehen ...
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
(Frontiers Media, 2022-10-18)
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...
Validation of an LC-ESI-MS/MS for the quantitation of phosphodiesterase-5 inhibitors and their main metabolites in rat serum and brain tissue samples.
(Elsevier, 2012-105-1)
This work proposes a liquid chromatography-electrospray ionization ion trap mass spectrometry (LC-ESI-ITMS) method, for the quantification of sildenafil (SDF), tadalafil (TDF) and vardenafil (VDF) and their metabolites ...