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CB1 and LPA(1) Receptors Relationship in the Mouse Central Nervous System
(Frontiers Media, 2019-09-19)
Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, ...
Handling and novel object recognition modulate fear response and endocannabinoid signaling in nucleus basalis magnocellularis
(Wiley, 2022)
[EN] Storage of aversive memories is of utmost importance for survival, allowing animals to avoid upcoming similar stimuli. However, without reinforcement, the learned avoidance response gradually decreases over time. ...
Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer’s Disease
(MDPI, 2021-11-12)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in aging populations. Recently, the regulation of neurolipid-mediated signaling and cerebral lipid species was shown ...
Neuroanatomical characterization of the G protein-coupled receptor activity evoked by galanin-related ligands
(Elsevier, 2023-03)
Galanin neuropeptide is distributed throughout the mammalian nervous system modulating a plethora of diverse physiological functions, including nociception, cognition and neuroendocrine regulation. The regulation of the ...
Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson’s Disease
(MDPI, 2023-03-13)
Multiple evidences suggest that mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease via the selective cell death of dopaminergic neurons, such as that which occurs after prolonged exposure ...
Specific phospholipid modulation by muscarinic signaling in a rat lesion model of Alzheimer's disease
(ACS. American Chemical Society, 2021-05-26)
La enfermedad de Alzheimer (EA) representa la causa más común de demencia en todo el mundo y se ha asociado sistemáticamente con la pérdida de neuronas colinérgicas del cerebro anterior basal (BFCNs) que conducen a una ...
Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain
(John Wiley & Sons, 2015-04-10)
El ácido lisofosfatídico (LPA) es una molécula de señalización que se une a seis receptores acoplados a proteínas G conocidos: LPA1 -LPA6 . El LPA evoca varias respuestas en el SNC, entre ellas el desarrollo y plegamiento ...
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
(Springer Verlag, 2011-01-28)
[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ...
Effects of galanin subchronic treatment on memory and muscarinic receptors.
(Elsevier, 2015-05-07)
Las vías colinérgicas, que se originan en el prosencéfalo basal y son responsables del control de diferentes procesos cognitivos como el aprendizaje y la memoria también están reguladas por algunos neuropéptidos. Uno de ...