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Brønsted Base Catalyzed One-Pot Synthesis od Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition
(Wiley-VCH, 2019-07-31)
Acatalyst-driven one-pot reaction sequence is
developed for the enantio- and diastereoselective synthesis of
tetrasubstituted cyclohexenes from simple unsaturated ketones
or thioesters.The method involves atertiary ...
Extended Enolates: Versatile Intermediates for Asymmetric C-H Functionalization via Noncovalent Catalysis
(Wiley, 2021)
Catalyst-controlled functionalization of unmodified carbonyl compounds is a relevant operation in organic synthesis, especially when high levels of site- and stereo-selectivity can be attained. This objective is now within ...
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
(Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ...
Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes
(MDPI, 2023-03-16)
Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, ...
Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma
(MDPI, 2023-02-14)
Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. ...
Progress in (Thio)urea‐ and Squaramide‐Based Brønsted Base Catalysts with Multiple H‐Bond Donors
(Wiley, 2023-02)
Nowadays chiral (thio)urea- and squaramide-based Brønsted base catalysts are widely applied to enantioselective carbon-carbon and carbon-heteroatom bond forming reactions. In recent years, variations of these catalysts ...
Organocatalytic Michael Addition of Unactivated α-Branched Nitroalkanes to Afford Optically Active Tertiary Nitrocompounds
(ACS, 2023-11-27)
The direct, asymmetric conjugate addition of unactivated α-branched nitroalkanes is developed based on the combined use of chiral amine/ureidoaminal bifunctional catalysts and a tunable acrylate template to provide tertiary ...
Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Brønsted Base Catalyzed Michael Reactions: α´-Hydroxy Enones as Key Enoate Equivalent
(ACS, 2014-11-25)
Catalytic and asymmetric Michael reactions constitute very powerful tools for the construction of new C–C bonds in synthesis, but most of the reports claiming high selectivity are limited to some specific combinations of ...
α-Hydroxy Ketones as Masked Ester Donors in Brønsted Base-Catalyzed Conjugate Additions to Nitroalkenes
(ChemPubSoc Europe, 2018-02-15)