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Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex

Alaimo Campi, Alessandro; Alberdi González, Araitz; Gomis Pérez, Carolina; Fernández Orth, Juncal; Bernardo Seisdedos, Ganeko; Malo de la Fuente, Covadonga; Millet Aguilar-Galindo, Oscar; Areso Goiricelaya, María Pilar; Villarroel Muñoz, Álvaro (Public Library Science, 2014-01-28)

Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, ...