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Desarrollo de un nuevo soporte polímerico con componentes de matriz extracelular neural para su aplicación en la diferenciación "in vitro" de distintas células primarias
(2012-07-11)
Este trabajo de Tesis Doctoral presenta el desarrollo, la caracterización y la validación de un nuevo soporte polimérico capaz de inducir la diferenciación neuronal in vitro, combinando técnicas de fotolitografía y de ...
Caracterización estructural de complejos ribosomales de iniciación y de pre-translocación mediante microscopía electrónica
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2012-07-04)
Los ribosomas son complejos macromoleculares altamente organizados responsables de la síntesis de proteínas en todos los organismos en un proceso llamado traducción. El término traducción hace referencia a que el lenguaje ...
PAnalyzer: A software tool for protein inference in shotgun proteomics
(BioMed Central, 2012-11-05)
Background
Protein inference from peptide identifications in shotgun proteomics must deal with ambiguities that arise due to the presence of peptides shared between different proteins, which is common in higher eukaryotes. ...
Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody : Implications for Anti-2F5 Immunogenicity
(Public Library of Science, 2012-12-21)
The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry ...
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family
(Portland Press LTD, 2012-01-01)
The mechanisms that regulate the nucleocytoplasmic localization of human deubiquitinases remain largely unknown. The nuclear export receptor CRM1 binds to specific amino acid motifs termed NESs (nuclear export sequences). ...
Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine
(American Society of Microbiology, 2012-06-15)
The nonstructural protein p7 of classical swine fever virus (CSFV) is a small hydrophobic polypeptide with an apparent molecular mass of 6 to 7 kDa. The protein contains two hydrophobic stretches of amino acids interrupted ...
Accumulated Bending Energy Elicits Neutral Sphingomyelinase Activity in Human Red Blood Cells
(Elservier, 2012-05-02)
[EN] We propose that accumulated membrane bending energy elicits a neutral sphingomyelinase (SMase) activity in human erythrocytes. Membrane bending was achieved by osmotic or chemical processes, and SMase activity was ...