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Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
(Frontiers Media, 2020-07-21)
Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ...
Microglial Phagocytosis Dysfunction in the Dentate Gyrus is Related to Local Neuronal Activity in a Genetic Model of Epilepsy
(Wiley, 2020-11)
Objective Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response during neurodegeneration. Whereas it is very efficient in physiological conditions, it is impaired in mouse ...