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Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin
(Impact Journals, 2020-04-15)
Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ...
Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis
(Oxford University Press, 2020-05)
Dmrt5 (Dmrta2) and Dmrt3 are key regulators of cortical patterning and progenitor proliferation and differentiation. In this study, we show an altered apical to intermediate progenitor transition, with a delay in SP ...
Inicio y progresión de la enfermedad de Parkinson: papel de la activación GLIAL
(2020-03-17)
La enfermedad de Parkinson (EP) se caracteriza por un déficit de dopamina en el estriado debido a la degeneración de neuronas dopaminérgicas en la sustancia negra pars compacta (SNpc) que proyectan al estriado. El marcador ...
Disruption of Oligodendrocyte Progenitor Cells is an Early Sign of Pathology in the Triple Transgenic Mouse Model of Alzheimer's Disease
(Elsevier, 2020-10)
There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte ...
Metabolic Alterations in Plasma from Patients with Familial and Idiopathic Parkinson's Disease
(Impact Journals LLC, 2020-09-15)
The research of new biomarkers for Parkinson's disease is essential for accurate and precocious diagnosis, as well as for the discovery of new potential disease mechanisms and drug targets. The main objective of this work ...
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
(MDPI, 2021-03-04)
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. ...
RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
(MDPI, 2021-03-12)
Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically ...
Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments
(Frontiers Media, 2021-01-29)
Dravet syndrome (DS) is an epileptic syndrome caused by mutations in the Scn1a gene encoding the alpha 1 subunit of the sodium channel Nav1.1, which is associated with febrile seizures that progress to severe tonic-clonic ...
Hippocampal Neural Stem Cells: from origin to disease. Postnaltal and on-site generation of adult hippocampal neural stem cells and blocking of the epidermal growth factor receptor to preserve neuroge
(2020-12-15)
En la presente tesis se han analizado por un lado el desarrollo, formación y establecimiento de las células madre neurales adultas del hipocampo en la zona subgranular del giro dentado, y por otro la respuesta de ésta ...
The Anti-Inflammatory Astrocyte Revealed: the Role of the Microbiome in Shaping Brain Defences
(Springer, 2021-04-10)
Astrocytes are a sub-type of neuroglia responsible for homoeostasis and defence of the nervous system. Pathological reactions of neuroglial cells in various neurological disorders have been identified and characterised in ...