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Calpain 3 in skeletal muscle regeneration: Potential role in satellite cells and in the myogenic differentiation of iPSC-derived muscle progenitors
(2017-12-18)
La distrofia de cinturas de tipo 2A (LGMD2A) es una enfermedad genética de herencia autosómicarecesiva, causada por mutaciones en el gen CAPN3, que codifica la proteasa muscular no lisosomalcalpaína 3. Los pacientes sufren ...
Microglial phagocytosis/apoptosis uncoupling in epilepsy: mechanisms and detrimental consequences
(2017-06-29)
La microglía es la célula inmune y el fagocito profesional del cerebro. La microglía es la encargada de fagocitar las células que mueren en el cerebro por apoptosis, o muerte programada. La fagocitosis de estas células es ...
Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease
(Frontiers Media, 2017-02-16)
The Calcium-Sensing Receptor (CaSR) is a G-protein coupled, 7-transmembrane domain receptor ubiquitously expressed throughout the body, brain including. The role of CaSR in the CNS is not well understood; its expression ...
Contributions made by physiotherapy to the design of a game-based technology solution as therapy for improvement in frailty in elderly persons
(2017-07-10)
The FRED game is a technological solution designed as a type of exergame for improvement in frailty in elderly persons, in which the physiotherapist, designed the contents of the game while at the same time taking into ...
Psychoeducational preventive treatment for women at risk of postpartum depression: study protocol for a randomized controlled trial, PROGEA
(Biomed Central, 2017-06-13)
Background: Postpartum depression is a disease with a prevalence of 20% that has deleterious consequences not only for the mother but also for the baby and can cause delays in physical, social and cognitive development. ...
Calcium Sensing Receptor, Calcium Binding Proteins and Astrocytic Changes in Alzheimers Disease.
(2017-05-31)
La enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa caracterizada por la pérdida de memoria y disfunciones cognitivas, entre las cuales se incluyen problemas del lenguaje, desorientación, pérdida de la ...
Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches
(MDPI, 2017-02)
Hypoxic-ischemic brain damage is an alarming health and economic problem in spite of the advances in neonatal care. It can cause mortality or detrimental neurological disorders such as cerebral palsy, motor impairment and ...
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
(Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ...
The Unexpected Co-Occurrence of GRN and MAPT p.A152T in Basque Families: Clinical and Pathological Characteristics
(Public Library Science, 2017-06-08)
Background
The co-occurrence of the c.709-1G > A GRN mutation and the p.A152T MAPT variant has been identified in 18 Basque families affected by frontotemporal dementia (FTD). We aimed to investigate the influence of ...