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Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene
(MDPI, 2016-12-13)
Menopause is a period of women's life characterized by the cessation of menses in a definitive way. The mean age for menopause is approximately 51 years. Primary ovarian insufficiency (POI) refers to ovarian dysfunction ...
Impacto del cambio en la actividad física en diferentes indicadores de resultados en pacientes con enfermedad pulmonar obstructiva crónica (EPOC)
(2019-03-07)
Los objetivos generales de la tesis se centran en tres aspectos: 1º Determinar el impacto del cambio en el nivel de actividad física en la calidad de vida relacionada con la salud en una corte de pacientes con EPOC. 2º ...
Gene Expression Study and Pathway Analysis of Histological Subtypes of Intestinal Metaplasia that Progress to Gastric Cancer
(Public Library Science, 2017-04-25)
Background
Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to ...
The Impact of Surgical Practice on Oncological Outcomes in Robot-Assisted Radical Hysterectomy for Early-Stage Cervical Cancer, Spanish National Registry
(MDPI, 2022-01-29)
This study aimed to assess whether surgical practice had a significant impact on oncological outcomes among women who underwent robot-assisted radical hysterectomy for early-stage cervical cancer (≤IB1 or IIA1, FIGO 2009). ...
Aspiration of excess follicles before intrauterine insemination in high response cycles
(Wiley, 2022)
Purpose To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4-6 follicles >= 14 mm. Methods A retrospective case-control study with ...
(Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis
(MDPI, 2019-06-24)
(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling. Its biological role has recently been related to cancer progression and in this ...
Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma
(BioMed Central, 2012)
Background:
Gastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies ...
Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma
(Elsevier, 2017-12)
Purpose: Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these ...
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
(Cell Press, 2018-04-19)
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ...
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
(Cell Press, 2018-04-19)
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with ...