Bilatu
56-tik 1-10 emaitza erakusten
Design of protein-nanomaterial hybrids as tools for sensing, imaging and bioelectronics
(2022-06-17)
El diseño de proteínas permite construir herramientas nanotecnológicas adaptadas para su uso en campos como la biomedicina o la industria. Las proteínas de repetición CTPR son una buena opción para desarrollar nano-herramientas ...
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
(Elsevier, 2022-01-16)
[EN] Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that ...
Estudio de la heterogeneidad histopatológica, genética y molecular en correlación con las características clínicas, radiológicas y terapéuticas en el impacto del estado funcional y de la supervivencia
(2022-01-28)
IntroducciónEl Glioblastoma es el tumor más frecuente y agresivo del sistema nervioso central con un pronóstico extremadamentesombrío; más de la mitad de los pacientes fallecen al año del diagnóstico, la mayoría antes de ...
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
(American Society of Clinical Investigation, 2022-04-01)
[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ...
Instauración del fundamento terapéutico de la inhibición de la vía de señalización Lefty-Smad en el Glioblastoma
(2022-04-21)
El Glioblastoma es el tumor cerebral primario más frecuente y agresivo del Sistema Nervioso Central. Presenta un pronóstico muy pobre, con una mediana de supervivencia menor a los 15 meses, y los costes en la sociedad ...
Implication of Ceramide Kinase/C1P in Cancer Development and Progression
(MDPI, 2022-01-04)
Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that ...
The Myth of The Annular Lipids
(MDPI, 2022-10-22)
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the ...
Label-Free Monitoring of Tumor Models by Surface-Enhanced Raman Scattering
(2022-05-13)
El objetivo general de la presente tesis se ha centrado en la monitorización de modelos celulares mediante la técnica de espectroscopia de Raman aumentada en superficies (SERS). Las tecnologías desarrolladas en la tesis ...
Four Cholesterol-Recognition Motifs in the Pore-Forming and Translocation Domains of Adenylate Cyclase Toxin Are Essential for Invasion of Eukaryotic Cells and Lysis of Erythrocytes
(MDPI, 2022)
Adenylate Cyclase Toxin (ACT or CyaA) is one of the important virulence factors secreted by Bordetella pertussis, the bacterium causative of whooping cough. ACT debilitates host defenses by production of unregulated levels ...
Conformational Rearrangements Regulating the DNA Repair Protein APE1
(MDPI, 2022)
Apurinic apyrimidinic endonuclease 1 (APE1) is a key enzyme of the Base Excision Repair (BER) pathway, which primarily manages oxidative lesions of DNA. Once the damaged base is removed, APE1 recognises the resulting abasic ...