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Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
(BMJ, 2018-09)
Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe ...
Associative mechanisms of transfer of extinction across contexts and stimuli: Studies on occasion setting and learning to learn.
(2018-12-14)
La evidencia científica muestra que el aprendizaje que se da durante la extinción de una respuesta previamente condicionada se transfiere con dificultad entre contextos. El efecto de renovación de respuesta es el mejor ...
LRRK2 Expression is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1
(Springer, 2018)
Mutations in PINK1 (PARK6), a serine/threonine kinase involved in mitochondrial homeostasis, are associated with early onset Parkinson's disease. Fibroblasts from Parkinson's disease patients with compound heterozygous ...
Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease
(Elsevier, 2018-08-31)
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and ...
Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning
(Springer Nature, 2018-06-12)
Striatal-enriched protein tyrosine phosphatase (STEP) modulates key signaling molecules involved in synaptic plasticity and neuronal function. It is postulated that STEP opposes the development of long-term potentiation ...