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Mass spectrometry-based proteomics strategies to define protein NEDDyltion
(2017-09-07)
Las modificaciones post-traduccionales reguladas por la ubiquitina y la familia de la ubiquitina estánimplicadas en diversas funciones vitales en las células eucariotas. Entre todas las proteínas de la familiade la ubiquitina, ...
Relevance of the transcription factor Sox9 in human breast epithelial cells, cancer stem cells and tamoxifen resistance
(2017-09-21)
El incremento de células madre de cáncer durante el desarrollo de la resistencia al tamoxifeno en cáncer de mama se debe a diferentes rutas de señalización, entre ellas, la activación de Sox2, dependiente de la ruta de ...
Living different lives: Early social differentiation identified through linking mortuary and isotopic variability in Late Neolithic/ Early Chalcolithic north-central Spain
(Public Library Science, 2017-09-27)
Variation in burial location and treatment is often observed in the prehistoric archaeological record, but its interpretation is usually highly ambiguous. Biomolecular approaches provide the means of addressing this ...
Putative Role of Respiratory Muscle Training to Improve Endurance Performance in Hypoxia: A Review
(Frontiers Media, 2019-01-15)
Respiratory/inspiratory muscle training (RMT/IMT) has been proposed to improve the endurance performance of athletes in normoxia. In recent years, due to the increased use of hypoxic training method among athletes, the RMT ...
Feasibility of mussel (Mytilus galloprovincialis Lmk.) aquaculture in the open waters of SE Bay of Biscay (Basque Country)
(2017-10-10)
Etorkizunean aurreikusten den giza populazioaren hazkundeak elikagaien ekoizpena handitzea eskatzen du eta bereziki, animali jatorrizko proteinen ekoizpena. Mytilus galloprovincialis Lmk. aukera naturala da Bizkaiko Golko ...
Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene
(MDPI, 2016-12-13)
Menopause is a period of women's life characterized by the cessation of menses in a definitive way. The mean age for menopause is approximately 51 years. Primary ovarian insufficiency (POI) refers to ovarian dysfunction ...
Metabolic implications and characterization of hepatic extracellular vesicles in drug-induced liver injury
(2015-07-28)
El daño hepático inducido por drogas (DILI) es un grave problema en las sociedadesdesarrolladas, siendo el responsable de más del 50% de los casos de fallo hepático agudo. Unárea de gran interés, tanto en el diagnóstico ...
Post-translational modifications by sumo and ubiquitin-like proteins; role of sumoylation on sall proteins
(2016-02-18)
Las modificaciones post-traduccional debidas a la conjugación de Ubiquitina y de proteínas similares a la Ubiquitina (UbLs) contribuyen a extender y diversificar la funcionalidad de los proteomas eucariotas. SUMO (Small ...
Disease-Associated SNPs in Inflammation-Related lncRNAs
(Frontiers Media, 2019-03-08)
Immune-mediated diseases, such as celiac disease, type 1 diabetes or multiple sclerosis, are a clinically heterogeneous group of diseases that share many key genetic triggers. Although the pathogenic mechanisms responsible ...
Physiological and molecular basis determining inter-individual growth rate differences in spat of the mussel Mytilus galloprovincialis reared under different nutritional and temperature environments.
(2018-12-05)
En el presente trabajo se exponen los resultados obtenidos en una serie de experimentos diseñados para confirmar o rechazar la hipótesis de que las características fisiológicas que generan diferencias entre individuos de ...