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Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
(Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ...
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
(Wiley, 2020-07-07)
[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased
in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence
has been associated with age-dependent hepatosteatosis. ...
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
(Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver
fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ...