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Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
(Frontiers Media, 2017-03-06)
Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version ...
Metastable Resting State Brain Dynamics
(Frontiers Media, 2019-09)
Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
A novel brain partition highlights the modular skeleton shared by structure and function
(Nature Publishing Group, 2015-06-03)
Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our ...
Snail heterogeneity in clear cell renal cell carcinoma
(Biomed Central, 2016-03-08)
Background: Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, ...
Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder
(Wiley, 2021-07)
Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. Autism spectrum disorder ...
Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation
(Nature, 2020-05-05)
Restoration of the communication between brain circuitry is a crucial step in the recovery of brain damage induced by traumatic injuries or neurological insults. In this work we present a study of real-time unidirectional ...
MMADHC Premature Termination Codons in the Pathogenesis of Cobalamin D Disorder: Potential of Translational Readthrough Reconstitution
(Elsevier, 2021-03)
Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients present methylmalonic aciduria ...
BRAF V600E mutational load as a prognosis biomarker in malignant melanoma
(Public Library Science, 2020-03-13)
Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ...
Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study
(Wiley, 2020-06)
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of ...
Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients
(MDPI, 2023-04-06)
This study set out to assess the performance of an artificial intelligence (AI) algorithm based on clinical data and dermatoscopic imaging for the early diagnosis of melanoma, and its capacity to define the metastatic ...