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Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies
(MDPI, 2011-03-03)
Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the ...
Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
(Frontiers Media, 2017-03-06)
Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version ...
Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients
(Elsevier, 2018-08)
Background: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile ...
Biofunctional iron oxide nanoparticles as vaccine adjuvants for enhanced anti-cancer immunotherapy
(2017-12-15)
En esta tesis se aborda el diseño y caracterización de una vacuna basada en nanoparticulas de óxido de hierro para su aplicación en inmunoterapia del cáncer. Concretamente, las nanoparticulas están biofuncionalizadas con ...
Proper Name Retrieval And Structural Integrity Of Cerebral Cortex In Midlife: A Cross-Sectional Study
(Elsevier, 2018-02)
There is currently little understanding on whether retrieval of proper names differs in midlife compared to young adulthood and if so, whether the age differences in this ability are associated with differences in structural ...
Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity
(Biomed Central, 2016-08-22)
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and ...
Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects
(MDPI, 2019-04-03)
The aim of this study is to assess if an adhesive biopolymer, sodium hyaluronate (NaHA), has synergistic effects with s-PRGF (a serum derived from plasma rich in growth factors and a blood derivative that has already shown ...
Metastable Resting State Brain Dynamics
(Frontiers Media, 2019-09)
Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
Normative Data for Test of Verbal Fluency and Naming on Ecuadorian Adult Population
(Frontiers Media, 2020-05-27)
Objective: To generate normative data for verbal fluency and naming test in an Ecuadorian adult population. Methods: The sample consisted of 322 healthy adults (18-84 years old) recruited from Quito, Ecuador. The verbal ...
Health-Related Quality of Life and Mental Health of Adolescents Involved in School Bullying and Homophobic Verbal Content Bullying
(MDPI, 2019-07-23)
Bullying has been traditionally related to a significant reduction in well-being and Health-Related Quality of Life (HRQoL) of adolescents. This negative impact on HRQoL seems to be modulated by the developed role in ...