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RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
(MDPI, 2021-03-12)
Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically ...
Neuropilin-1: A feasible link between liver pathologies and COVID-19
(Baishideng Publishing Group, 2021-06-28)
[EN] The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
has a tremendous impact on the health of millions of people worldwide. Unfortunately,
those suffering from previous pathological conditions ...
Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder
(Wiley, 2021-07)
Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. Autism spectrum disorder ...
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels’ Activation in Breast Cancer Cells
(MDPI, 2021-04-01)
The intracellular calcium concentration ([Ca2+]i) modulation plays a key role in the regulation of cellular growth and survival in normal cells and failure of [Ca2+]i homeostasis is involved in tumor initiation and ...
Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
(Korean Society of Applied Pharmacology, 2021-05)
Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion. ...
PREparedness, REsponse and SySTemic transformation (PRE-RE-SyST): a model for disability-inclusive pandemic responses and systemic disparities reduction derived from a scoping review and thematic analysis
(Springer Nature, 2021-09-14)
Background People with disabilities (PwD) have been facing multiple health, social, and economic disparities during the COVID-19 pandemic, stemming from structural disparities experienced for long time. This paper aims to ...
Characterisation of corneas following different time and storage methods for their use as a source of stem-like limbal epithelial cells
(Elsevier, 2021-10)
The transplantation of expansions of limbal epithelial stem cells (LESC) remains one of the most efficient therapies for the treatment of limbal stem cell deficiency (LSCD) to date. However, the available donor corneas are ...
Enzyme Therapy: Current Challenges and Future Perspectives
(MDPI, 2021-08-25)
In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular ...
Local translation in nervous system pathologies
(Frontiers Media, 2021-06-29)
[EN] Dendrites and axons can extend dozens to hundreds of centimeters away from the
cell body so that a single neuron can sense and respond to thousands of stimuli.
Thus, for an accurate function of dendrites and axons ...
Cytocompatibility and Suitability of Protein-Based Biomaterials as Potential Candidates for Corneal Tissue Engineering
(MDPI, 2021-03-31)
The vision impairments suffered by millions of people worldwide and the shortage of corneal donors show the need of substitutes that mimic native tissue to promote cell growth and subsequent tissue regeneration. The current ...