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S-adenosylmethionine: a metabolic driver in liver lipid metabolism and VLDL clearance
(2017-10-30)
La enfermedad del hígado graso no alcohólica, EHGNA o NAFLD, es la causa más frecuente en el mundo de enfermedad crónica hepática. Su desarrollo se ha asociado en algunos casos a un metabolismo errático de S-Adenosilmetionina ...
Understanding the role of miRNAs in the hallmarks of cancer using functional screens.
(2017-09-15)
En ésta tesis hemos estudiado la función de los miRNAs en las principales características o "hallmarks"del cáncer. Para ello hemos realizado cribados funcionales con una librería lentiviral para la sobreexpresiónde miRNAs ...
Effects of a physical activity programme to prevent physical performance decline in onco‐geriatric patients: a randomized multicentre trial
(2019-03)
BACKGROUND: Older adults with cancer experience negative long-term functional effects of both cancer and treatments. Exercise may minimize their age-related and cancer-related functional decline.
METHODS: We conducted ...
Effects of a physical activity programme to prevent physical performance decline in onco-geriatric patients: a randomized multicentre trial
(Wiley, 2019-04)
Background Older adults with cancer experience negative long-term functional effects of both cancer and treatments. Exercise may minimize their age-related and cancer-related functional decline. Methods We conducted a ...
Association of Birth Order with Cardiovascular Disease Risk Factors in Young Adulthood: A Study of One Million Swedish Men
(Public Library of Science, 2013-05-16)
Background: Birth order has been suggested to be linked to several cardiovascular disease (CVD) risk factors, but the evidence is still inconsistent. We aim to determine the associations of birth order with body mass index ...
Osteopontin: a key regulator of liver lipid metabolism
(2016-04-25)
Osteopontin deficiency protects from obesity-related hepatosteatosis and liver fibrosis. Here we have investigated the role of osteopontin as a direct regulator of liver metabolism and whether osteopontin could be a ...
Long-term mortality in hospitalized patients with community-acquired pseumonia
(2017-02-20)
La neumonía adquirida en la comunidad (NAC) es un importante problema de salud pública con una elevada morbi-mortalidad. La incidencia anual oscila entre dos y ocho por cada 1000 habitantes. En Estados Unidos, junto con ...
Added Sugars and Low- and No-Calorie Sweeteners in a Representative Sample of Food Products Consumed by the Spanish ANIBES Study Population
(MDPI, 2018-09-07)
Low- and no-calorie sweeteners (LNCS), intensely sweet compounds that virtually contain no calories, are used to replace added sugars in food and drinks. Knowledge about different LNCS data in Spanish foods and added sugar ...
Novel insights in the pathogenesis of primary biliary cholangitis and cholangiocarcinoma
(2017-06-23)
Este trabajo de tesis doctoral se centra en el estudio de dos enfermedades biliares: la colangitis biliar primaria (del inglés primary biliary cholangitis, PBC) y el colangiocarcinoma (CCA).Por un lado, ya que el miR-506 ...
Application of Bioactive Thermal Proteome Profiling to Decipher the Mechanism of Action of the Lipid Lowering 13(2)-Hydroxy-pheophytin Isolated from a Marine Cyanobacteria
(MDPI, 2019-06-21)
The acceleration of the process of understanding the pharmacological application of new marine bioactive compounds requires identifying the compound protein targets leading the molecular mechanisms in a living cell. The ...