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Chemoenzymatic synthesis and immunological studies of Xylosylated N-glycans
(2016-06-07)
Glycosylation is one of the most common post-translational modifications in eukaryotic cells. It changes during cell development and differentiation and it is tissue and more importantly, species specific. While core ¿-1,6 ...
New challenges in the synthesis of non-isocyanate polyurethanes
(2018-12-18)
Entre todos los materiales plásticos, los poliuretanos (PU) representan el sexto polímero más utilizado en el mundo; se sintetizan industrialmente mediante la reacción entre un diol y un diisocianato, en presencia de un ...
Synthesis, applications and reactivity of 1,2,3-triazolium salts
(2015-07-10)
La tesis aborda los siguientes aspectos de la química de las sales de 3-alquil-1,2,3- triazolio:a) El estudio de nuevos alquinos catiónicos de 4-etinil-3-metil-1,2,3-triazolio como dipolarófilos en la reacción de cicloadición ...
Solid-phase synthesis of glicosaminoglycans
(2017-09-15)
Glycosaminoglycans (GAGs) are highly charged and linear polysaccharide repeating units (with the exception of keratin sulfate), which are further classified according their monosaccharide composition and glycosidic linkage. ...
Co-Catalyzed C(sp3)−H Oxidative Coupling of Glycine and Peptide Derivatives
(American Chemical Society, 2017-09-22)
obalt-catalyzed selectiveα-alkylation andα-heteroarylation processes ofα-amino esters and peptide derivativesare described. These cross-dehydrogenative reactions occur undermild conditions and allow for the rapid assembly ...
Iron-Catalyzed Direct α-Arylation of Ethers with Azoles
(Royal Society of Chemistry, 2015-07-14)
The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient ...
Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide
(MDPI, 2018-12-12)
A primary amine-salicylamide derived from chiral trans-cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly ,-disubstituted to N-substituted maleimides. The ...
Unprecedented Multicomponent Organocatalytic Synthesis of Propargylic Esters via CO2 Activation
(Wiley‐VCH, 2019-02-19)
An efficient and straightforward organocatalytic method for the
direct, multicomponent carboxylation of terminal alkynes with
CO2 and organochlorides, towards propargylic esters, is reported
for the first time. ...
An umpolung strategy to react catalytic enols with nucleophiles
(Nature, 2019-11-20)
The selective synthesis of a-functionalized ketones with two similar enolizable positions can be accomplished using allylic alcohols and iridium(III) catalysts. A formal 1,3-hydrogen shift on allylic alcohols generates ...
Selective C(sp2)−H Halogenation of "click" 4-Aryl-1,2,3-triazoles
(American Chemical Society, 2017-02-09)
Selective bromination reactions of “click compounds” are described. Electron-neutral and electron-deficient arenes selectively undergo unprecedented Pd-catalyzed C–H ortho-halogenations assisted by simple triazoles as ...