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Contextualization of the Bioeconomy Concept through Its Links with Related Concepts and the Challenges Facing Humanity
(MDPI, 2021-07-12)
The concept of bioeconomy is a topic of debate, confusion, skepticism, and criticism. Paradoxically, this is not necessarily a negative thing as it is encouraging a fruitful exchange of information, ideas, knowledge, and ...
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
(Nature, 2020-08-20)
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused ...
Design of protein-nanomaterial hybrids as tools for sensing, imaging and bioelectronics
(2022-06-17)
El diseño de proteínas permite construir herramientas nanotecnológicas adaptadas para su uso en campos como la biomedicina o la industria. Las proteínas de repetición CTPR son una buena opción para desarrollar nano-herramientas ...
Proteostasis and Rare Diseases: Congenital Erythropoietic Porphyria and Townes-Brocks Syndrome
(2020-07-28)
El término proteostasis se refiere a todos aquellos procesos biológicos críticos para el buen funcionamiento de la célula. La alteración de las vías reguladoras de la proteostasis puede afectar seriamente la función celular ...
Multivalency Transforms SARS-CoV-2 Antibodies Into Ultrapotent Neutralizers
(Nature, 2021-06-16)
SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies
can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin
protomer as a modular subunit to drive ...
Antibiotic Resistance in Agricultural Soil and Crops Associated to the Application of Cow Manure-Derived Amendments from Conventional and Organic Livestock Farms
(Frontiers Media, 2021-02-23)
he application of organic amendments to agricultural soil can enhance crop yield, while improving the physicochemical and biological properties of the recipient soils. However, the use of manure-derived amendments as ...
Study of the role transmembrane domain of Type IV Coupling Proteins
(2020-07-10)
La conjugación bacteriana es el mecanismo más importante en la diseminación de genes de resistencia a antibióticos entre bacterias. Este proceso se realiza mediante unos complejos macromoleculares denominados Sistemas de ...
Identificación of ERBB4 and SOX1 role in central nervous system tumors. Implication in medulloblastoma and glioblastoma.
(2020-12-16)
Los tumores cerebrales, como el glioblastoma (GBM) en adultos y el meduloblastoma (MB) en niños, representan uno de los retos más importantes de la medicina actual, ya que resisten a las terapias disponibles, recurren y ...
Aberrant Synaptic PTEN in Symptomatic Alzheimer's Patients May Link Synaptic Depression to Network Failure
(Frontiers Media, 2021-05-11)
In Alzheimer's disease (AD), Amyloid beta (A beta) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD). There is now evidence from AD models that A beta ...