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Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation
(American Society for Biochemistry and Molecular Biology, 2018-12)
Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates ...
An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
(Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ...
Chromosomes trapped in micronuclei are liable to segregation errors
(Company Biologist LTD, 2018-07-09)
DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis. Here, we ...