Search
Now showing items 1-10 of 99
Decreased Striatal Adenosine A(2A)-Dopamine D(2)Receptor Heteromerization in Schizophrenia
(Springer Nature, 2020-10-03)
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be ...
Di-aryl guanidinium derivatives: Towards improved α2-Adrenergic affinity and antagonist activity
(Elsevier, 2021-01-01)
Compounds with excellent receptor engagement displaying alpha(2)-AR antagonist activity are useful not only for therapeutic purposes (e.g. antidepressants), but also to help in the crystallization of this particular GPCR. ...
Calcium-binding proteins are altered in the cerebellum in schizophrenia
(Public Library Science, 2020-07-08)
Alterations in the cortico-cerebellar-thalamic-cortical circuit might underlie the diversity of symptoms in schizophrenia. However, molecular changes in cerebellar neuronal circuits, part of this network, have not yet been ...
Electrophysiological characterization of neuronal diversity in the substantia nigra pars reticulata in control and parkinsonian mice.
(2020-06-18)
Los ganglios de la base son un conjunto de núcleos conectados entre sí que conforman un circuito neuronal encargado de controlar el movimiento voluntario. La substantia nigra pars reticulata (SNr) forma parte de este ...
Editorial: Non-Dopaminergic Systems in Parkinson's Disease
(Frontiers Media, 2020-09-11)
The dopaminergic system has been the main focus for almost 70 years and dopaminergic-based strategies still remain the best symptomatic medication to improve quality of life of parkinsonian patients.
A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users
(Nature Research, 2021-10-07)
[EN]Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable ...
Oral and Palmitate Paliperidone Long-Acting Injectable Formulations’ Use in Schizophrenia Spectrum Disorders: A Retrospective Cohort Study from the First Episode Psychosis Intervention Program (CRUPEP)
(Oxford University Press, 2021)
Background: Long-acting injectable antipsychotics (LAIs) may be a suitable therapeutic option for those patients in earlier stages of psychosis to avoid relapses and disease progression. Despite that, there is a lack of ...
Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
(Frontiers Media, 2021-05-13)
Emerging evidence indicates that early-life exposure to environmental factors may increase the risk for schizophrenia via inflammatory mechanisms. Inflammation can alter the metabolism of tryptophan through the oxidative ...
Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum
(MDPI, 2021-12-23)
Long-term exposition to morphine elicits structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, morphine-induced neuroadaptations in the dorsal striatum ...
Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study
(Taylor & Francis, 2022)
[EN] Background Interindividual genetic variations contribute to differences in patients' response to drugs as well as to the development of certain disorders. Patients who use non-steroidal anti-inflammatory drugs (NSAIDs) ...