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Membrane-Bound sn-1,2-Diacylglycerols Explain the Dissociation of Hepatic Insulin Resistance from Hepatic Steatosis in MTTP Knockout Mice
(American Society for Biochemistry and Molecular Biology, 2020-12)
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between ...
Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
(2022-06-17)
El colangiocarcinoma (CCA) es un cáncer biliar raro y heterogéneo, con una incidencia y mortalidad creciente. Este estudio investiga el curso natural de CCA y sus subtipos en una cohorte paneuropea. El estudio incluyó 2.234 ...
The contribution of daytime sleepiness to impaired quality of life in NAFLD in an ethnically diverse population
(Nature, 2022-03-24)
Health-related quality of life (HRQoL) is lower in people with NAFLD compared to the general population. Sleep disturbance resulting in daytime sleepiness is common in patients with NAFLD, but the effect of daytime sleepiness ...
Dantza eta ibiltzearen arteko desberdintasun sentsoriomotore eta neuropsikologikoak adineko emakumeetan
(2020-07-17)
El deterioro de la salud relacionado con el envejecimiento afecta más y en mayor medida a las mujeres. Las diferencias en la función sensoriomotriz y neuropsicológica en las personas mayores podrían estar relacionadas con ...
Allostatic hypermetabolic response in PGC1 alpha/beta heterozygote mouse despite mitochondrial defects
(Wiley, 2021-09)
Aging, obesity, and insulin resistance are associated with low levels of PGC1 alpha and PGC1 beta coactivators and defective mitochondrial function. We studied mice deficient for PGC1 alpha and PGC1 beta [double heterozygous ...
Genetics of Somatotype and Physical Fitness in Children and Adolescents
(Wiley, 2021-05)
Objectives To analyze the influence of genetic and environmental factors on the variation in somatotype, physical fitness, and their mutual associations. Methods Twins from 214 pairs (87 monozygotic) of the Autonomous ...
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
(Elsevier, 2020-11-05)
Summary
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialised societies; this is likely
secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD), its progressive form ...
Systematic analysis of chemical-protein interactions from zebrafish embryo by proteome-wide thermal shift assay, bridging the gap between molecular interactions and toxicity pathways
(Elsevier, 2021-10-30)
[EN]The molecular interaction between chemicals and proteins often promotes alteration of cellular function. One of the challenges of the toxicology is to predict the impact of exposure to chemicals. Assessing the impact ...
Anti-TNFα treatment in Crohn’s disease: Impact on hepatic steatosis, gut-derived hormones and metabolic status
(Wiley, 2021-11)
Background and Aims An association between Crohn's disease (CD) and hepatic steatosis has been reported. However, the underlying mechanisms of steatosis progression in CD are not clear. Among the most effective CD treatments ...